Spectrophotometric determination of diphenhydramine hydrochloride in pharmaceutical preparations and biological fluids via ion-pair formation

El‐Didamony, Akram M.; Moustafa, Moftah A.

doi:10.1016/j.arabjc.2010.06.014

Cited by 36 publications

(20 citation statements)

References 27 publications

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“…Methods that use reactions between different dyes and diphenhydramine are based on the formation of a complex between anionic dyes and positively charged basic groups in acid medium, which results in a coloured complex with strong absorption in the visible range of electromagnetic spectrum [8][9][10][11]. Although they present appropriate parameters of validation, they also exhibit some limitations in formulations where active ingredients are mixed with diphenhydramine-like basic groups.…”

Section: Discussionmentioning

confidence: 99%

“…Some methods for diphenhydramine analysis propose the extraction of a coloured complex formed between the analyte and some dye, such as eriochrome black T, bromocresol purple, methyl orange, bromocresol green and rose bengal, using organic solvents. These methods provide an improved capacity of detection and drug selectivity, but their extraction requires the use of an organic solvent of the formed complex [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Analytical Method Development by Solid Phase Extraction and High-Performance Liquid Chromatography for Diphenhydramine Quantification in Syrups

Hurtado

Medina

2017

Int J App Pharm

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Objective: To develop a method for the determination of diphenhydramine hydrochloride in syrups. Methods:The developed method is based on the active ingredient recovery from the pharmaceutical formulation using a cartridge for selective solid phase extraction. This procedure is simple and fast as compared to the methods that require liquid/liquid extraction. Once the sample is eluted from the cartridge, it is injected directly into a reversed-phase chromatographic system containing a mixture of acetonitrile: 10 mmol ammonium acetate: triethylamine 60:39.5:0.5. Results:The proposed method fulfilled the validation parameters (linearity R 2 Conclusion:The proposed method proved to be reliable when it was applied in the quantification of diphenhydramine hydrochloride of two commercial syrup products.>0.99, precision CV<2% and accuracy 98-102%).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analytical Method Development by Solid Phase Extraction and High-Performance Liquid Chromatography for Diphenhydramine Quantification in Syrups

Hurtado

Medina

2017

Int J App Pharm

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“…Ion-pair methods using BPB and BTB Extractive spectrophotometric procedures due to their sensitivity are widely used in the assay of drugs and hence, ion-pair extractive spectrophotometry has received a considerable attention for the quantitative determination of many pharmaceutical compounds [30][31][32][33][34] . TRH reacts with BPB and BTB in an acidic buffer to give methylene chloride soluble ion-pair complexes, which exhibit absorption maxima at 405 and 408 nm for BPB and BTB, respectively.…”

Section: B-mentioning

confidence: 99%

Two Selective Spectrophotometry Methods for the Determination of Thioridazine Hydrochloride in Tablets and in Biological Fluids

El‐Didamony

Moustafa

2012

J. Chil. Chem. Soc.

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Two simple, rapid and selective spectrophotometric methods have been developed for the analysis of the psychoactive drug thioridazine HCl (TRH) in tablets and in biological fluids. The first method is based on the oxidation of TRH by a known excess of N-bromosuccinimide (NBS), followed by the determination of unreacted oxidants by measuring the decrease in absorbance of two different dyes; amaranth (AM) and methylene blue (MB) at a suitable l max 520 and 660 nm, respectively. Beer-Lambert plots showed good correlation in the concentration ranges of 0.8-4.8 and 0.8-5.6 µg/ml for AM and MB methods, respectively. The second method is based upon the formation of an ion-pair complexes (1: 1) with the acidic sulphonphthalein dyes bromophenol blue (BPB) and bromothymol blue (BTB). The formed complexes were extracted into methylene chloride and their absorbance was measured at 405 and 408 nm for BPB and BTB, respectively. Beer's law was obeyed with a good correlation coefficient (r = 0.9995-0.9989) in the concentration ranges of 4 -24 µg/ml for both BPB and BTB methods, respectively. All measurements of the two procedures are carried out in an acidic medium at room temperature. Optimizations of the different experimental conditions are described for both methods. The two methods have been successfully applied to the determination of thioridazine HCl in pharmaceutical, serum and urine samples and average recoveries are in the range of 98.12 -102.55%. Analytical results obtained with this novel method are satisfactory.

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“…Patches were applied on the receiver compartment with 17.5-ml phosphate buffer solution (pH 7.4) and a diffusion area of 3.14 cm 2 . Ten percent ethanol (v/v) was added in the buffer solution to increase capsaicin solubility in receiver compartment (15). The receiver compartment was stirred at a constant speed of 200 rpm.…”

Section: Drug Release Experimentsmentioning

confidence: 99%

“…Liquid paraffine, a low molecular weight plasticizer, is added in the formulation to reduce the melt temperature and the peel force (3). Three ordinary topical drugs, methyl salicylate (MS), diphenhydramine hydrochloride (DPH), and capsaicin (CS) are selected as model drugs to evaluate the different drug release profiles (13)(14)(15). The chemical structures of the drugs are shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Drug Release Profile from Patches Based on Styrene–Isoprene–Styrene Block Copolymer: The Effect of Block Structure and Plasticizer

et al. 2012

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Abstract. We prepared pressure-sensitive adhesive (PSA) patches based on styrene-isoprene-styrene (SIS) thermoplastic elastomer using hot-melt coating method. The liquid paraffine is added in the PSA matrices as a plasticizer to moderate the PSA properties. Three drugs, methyl salicylate, capsaicin, and diphenhydramine hydrochloride are selected as model drugs. The Fourier transform infrared spectroscopy, differential scanning calorimetry test, and wide-angle X-ray diffraction test indicate a good compatibility between drugs and matrices. Peppas equation is used to describe drug release profile. Different drug-matrix absorption, as indicative of drug-matrix interaction, accounts for the variation in release profiles of different drugs. Furthermore, atomic force microscopy and rheological studies of the PSA samples are performed to investigate the effect of SIS structure and plasticizer of PSA on drug release behaviors. For methyl salicylate and capsaicin, drug diffusion in the PSA matrices is the main factor controlled by the release kinetic constant k. The high [SI] diblock content and high plasticizer amount in matrix provide the PSA with a homogeneous and soften microstructure, resulting in a high diffusion rate. But for water-soluble drugs such as diphenhydramine hydrochloride, the release rate is governed by water penetration with the competition from diffusion mechanisms.

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Spectrophotometric determination of diphenhydramine hydrochloride in pharmaceutical preparations and biological fluids via ion-pair formation

Cited by 36 publications

References 27 publications

Analytical Method Development by Solid Phase Extraction and High-Performance Liquid Chromatography for Diphenhydramine Quantification in Syrups

Analytical Method Development by Solid Phase Extraction and High-Performance Liquid Chromatography for Diphenhydramine Quantification in Syrups

Two Selective Spectrophotometry Methods for the Determination of Thioridazine Hydrochloride in Tablets and in Biological Fluids

Evaluation of Drug Release Profile from Patches Based on Styrene–Isoprene–Styrene Block Copolymer: The Effect of Block Structure and Plasticizer

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