Spectrophotometric determination of metoclopramide medicine in bulk form and in pharmaceuticals using orcinol as reagent

Abstract

A modern, accurate, simple and sensitive spectrophotometric procedure is tested for the appreciation of metoclopramide medicine as perspicuous form, as well as in various kinds of pharmaceutical dosages. The procedure depends on the interaction of metoclopramide (MCP) medicine and orcinol reagent by utilizing azo coupling reaction. The orcinol in NaOH solution middle to give a latterly ligand which reacts with copper (II) to output the complex with strong yellow color at 50°C. The resulting complex is water soluble, stable and can be determined spectrophotometrically at wavelength 459 nm. The calibration curve absorbance vs. concentration was established in the concentration range 0.6-12 ppm, and the curve followed the Beer’s law in this range. The procedure precision is given by the average recovery of 99.91% sequentially, as well as by the average relative standard deviation 0.70%, related to the amount of drug. The sensitivity is established at molar absorptivity 1.9044×104 l‧cm-1‧mol-1. The Sandell sensitivity is tested as 0.002 μg/cm2. The analytical results for the tested procedure agree with the official procedure. The interferences from medicine additives were tested. The established procedure is successfully examined on the appreciation of MCP in diverse kinds of pharmaceuticals.

Utilization of Spectrophotometric Technique for the Quantitative Evaluation of Cefadroxil Monohydrate in its Pure form and Its Therapeutic Doses

“…Investigational findings revealed no interference with the experimental technique by excipients (Table 7). (Taha et al, 2016).…”

Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations Using Diazotization Coupling Reaction

“…The most used analytical techniques for MCPD measurement using various reagents are spectrophotometric approaches. Many studies have published techniques employing various reagents such as 3,5-Dimethylphenol [8], 4-Nitrophenol [9], 1-Naphthol [10], p-Nitroaniline [11], Orcinol [12], Iminodibenzyl, and 3-Chloroiminodibenzyl [13] for the majority of the reactions utilized for the detection of MCPD in pharmaceuticals.…”

Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Preparations Via Schiff ’s Base Reaction

“…Metoclopramide is a widely used medication in outpatient treatment and hospitalization for its antiemetic properties, was also used to reduce the period of the first stage of labor in primitive women, for stomach and esophageal problems and is a dopaminereceptor blocker [1][2][3][4].…”