Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pure and Pharmaceutical Preparations Using Diazo-coupling Reaction

Al-Ghabsha, Thabit S.; Obedagha, Aseel N.; Zakaria, Rawaa A.

doi:10.33899/edusj.1999.163319

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Several spectrophotometric methods have also been employed to the assay of OXM in bulk and its pharmaceutical preparations used various reagents for determining OXM, these reagents included: 2,6-dichloroquinone chlorimide with an oxidant reagent (Sankar et al, 1987), potassium ferricyanide -Fe(III) (Othman and Sahar, 2013), 4-chloro-7-nitrobenzo-2-oxa-1, 3-diazole (Salama et al, 2018), 2,4,6-tris(2-pyridyl)-5-triazine (Sankar et al, 1988), 2,4-dinitrophenylhydrazine (Humeidy, 2015), 1,10phenanthroline -iron(III) (Al-Sabha and Rasheed, 2011), 4-aminoantipyrine (Zakaria, 2011), cobaltinitrite-Na (Shingbal and Naik, 1983), cerium sulphate (IV) (Mohammed and Ikram, 2016) and 2,2-bipyridyl (Basheer and Mohammed, 2018). Some of these methods suffer from various limitations, for example, low sensitivity, and a long time to complete the reaction, and low stability of the product.…”

Section: Fig 1: Oxymetazoline Hydrochloridementioning

confidence: 99%

Spectrophotometric assay of oxymetazoline-HCl in pure form and in its pharmaceutical formulations using potassium permanganate.pdf

Basheer,

Mohammed

2022

LJST

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This study involves the development of two sensitive and reproducible spectrophotometric methods to determine oxymetazoline- HCl in pure form and its dosage forms. Both spectro-photometric methods were based on the reduction of potassium permanganate with oxymet-azoline- HCl.In method (A), oxymetazoline-HCl was reacted with an excess known amount of potassium permanganate in an acid solution of H2SO4 and the absorbance of unreacted potassium per-manganate was measured at 545 nm. In method (B) the oxidation reaction of oxymetazoline- HCl was carried out in an alkaline solution of sodium hydroxide and the absorbance of the resulting (MnO2) was measured at 610 nm. In method (A), the amount of potassium perman-ganate reacted corresponds to the oxymetazoline-HCl content and the intensity of absorb-ance decreased linearly with the concentration, while in method (B), the intensity of absorb-ance was increased linearly with concentration.Under optimum conditions, Beer’s law was found to be linear in the concentration range of 1.0-30 and 0.5-3.5 μg/ml with molar absorptivity 0.64×104 and 3.16×104 l.mol-1cm-1and cor-responding to Sandell's sensitivity values of 0.0448 and 0.0090 μg/cm2 for both methods (A) and (B), respectively. The detection limit (LOD) and quantification limit (LOQ) have also been estimated. Accuracy for pure OXM was calculated and found in the range -0.7% to 0.8% and-2.68% to 0.614%, while the precision (RSD) was <0.176% and <0.929% for method (A) and method (B), respectively. The two suggested methods (A) and (B) were successfully applied to the determination of oxymetazoline -HCl in bulk and its pharmaceutical preparations (drops and spray) with accurate and accepted results.

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Section: Fig 1: Oxymetazoline Hydrochloridementioning

confidence: 99%

Spectrophotometric assay of oxymetazoline-HCl in pure form and in its pharmaceutical formulations using potassium permanganate.pdf

Basheer,

Mohammed

2022

LJST

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New Green Modalities of Flow Injection Technology for Assaying Anti-Allergic Drugs in Pharmaceutics and Biological Samples

L. Hamed,

B. Qassim

2023

IHJPAS

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A new approach and the developed FIA technique with many advantages (economic, fast, simple, accurate, and high throughput) are used to determine the decongestant drugs (Phenylephrine.HCl, Oxymetazoline.HCl) in biological samples, pharmaceutical formulations, and pure samples via continuous flow injection technique by oxidative coupling reaction, where the method depends on the interaction of the decongestant drug with organic reagents to produce colored compounds, where Phenylephrine reacts with 4-AAP at λmax503 nm to produce a red compound, and the Beer’s law range of 10-600 μg.mL-1 . As for Oxymetazoline, it reacts with DNPH at λmax 631nm to produce a green compound with a linear dynamic range of 5-400 μg/mL. The limits of detection were 9.24 and 4.67 μg.mL-1, respectively. The veracity of recovery (%) was 100.24, 100.68, RSD% were 3.44, 2.51 and sampling was 60,77 sample.h-1 for PHE and OXY successively. Distilled water was used as a carrier to transport chemicals within the minute ports of the new system. Statistical data treatment using analysis of variance one-way ANOVA was used for the determination of drugs in dosage forms, and the results obtained were compared with the official method (AOAC) and British pharmacopeia.

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Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pure and Pharmaceutical Preparations Using Diazo-coupling Reaction

Cited by 2 publications

References 5 publications

Spectrophotometric assay of oxymetazoline-HCl in pure form and in its pharmaceutical formulations using potassium permanganate.pdf

Spectrophotometric assay of oxymetazoline-HCl in pure form and in its pharmaceutical formulations using potassium permanganate.pdf

New Green Modalities of Flow Injection Technology for Assaying Anti-Allergic Drugs in Pharmaceutics and Biological Samples

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