Spectrophotometric Determination of Phenylephrine  Hydrochloride by Coupling with Diazotized 2- Aminobenzothiazole

Fatah, Noha Th. Abdul; Othman, Nabeel S.

doi:10.33899/rjs.2009.39971

Cited by 6 publications

(1 citation statement)

References 19 publications

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“…Most researches are described utilizing spectrophotometric methods for estimating PPH in the bulk and in its pharmaceutical formulations using different reactions and various reagents. Some of these methods involve diazotization and coupling reaction (19)(20)(21)(22)(23)(24). Other methods base on the oxidative coupling reaction of PPH with 4-aminoantipyrine and potassium ferricyanide to yield dirty ping water soluble product (25), N,N-dimethyl-p-phenylenediamine in the presence of sodium persulfate in basic medium to give panic solution soluble product with maximum absorbance at 502 nm (26), and N,N-dimethyl-pphenylenediamine dihydrochloride with ferric chloride in basic media to form green-blue soluble dye product (27,28).…”

Section: Introductionmentioning

confidence: 99%

Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms

HAMEED,

ALİ

2023

Journal of the Turkish Chemical Society Section A: Chemistry

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This work includes the development of two spectrophotometric methods which are sensitive, accurate, stable, and has good recovery for the determination of phenylephrine-HCl as free form and in the pharmaceutical preparations. In the method (A), phenylephrine is oxidized by potassium permanganate in a basic solution of sodium hydroxide and the bluish-green color of the resulting manganate (MnO 42- ) is measured at wavelength 610 nm, which is linearly proportional to the amount of phenylephrine-HCl. Method (B), is involved the oxidation of phenylephrine-HCl by using an excess amount of N-bromosuccinimide in an acidic medium of hydrochloric acid solution, the remaining (unreacted) amount of N-bromosuccinimide is used to bleach indigo carmine dye and the absorbance of the blue color of the remaining dye is measured at the wavelength of 610 nm. which is directly proportional to the concentration of phenylephrine-HCl. The molar absorptivity coefficients of methods (A) and (B) are estimated and equal to 1.5722×10 4 and 5.5191×10 4 L/mol.cm, respectively. Beer’s law of the both methods are linear in the concentration ranges 0.2–8.0 µg/mL (method A) and 0.2–3.5 µg/mL (method B). The relative standard deviation values of methods (A) and (B) are also found to be better than 0.0286 and 0.0114, respectively. The two proposed methods are applied to estimate phenylephrine-HCl in injection and drop.

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Section: Introductionmentioning

confidence: 99%

Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms

HAMEED,

ALİ

2023

Journal of the Turkish Chemical Society Section A: Chemistry

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Determination of Phenylephrine-HCl Using Conductometric Titration Method

Hasan

Othman²,

Surchi³

2016

CAC

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Development of Spectrophotometric Method to Assay Phenylephrine Hydrochloride in Pure and in its Pharmaceutical Forms Using Diazotized Sulphanilic Acid

Hanan H.,

Mohammed

2024

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This work described a simple and sensitive spectrophotometric procedure for estimating phenylephrine hydrochloride in pure and in its pharmaceutical using diazotized sulphanilic acid as a coupling agent in alkaline medium of sodium carbonate solution. The resulting yellow azo-dye displayed an absorption maximum at 441 nm. The calibration graph was linear and compatible to Beer's law over the concentration range 0.2-20 µg/mL with coefficient estimated (r2=0.9996). The values of molar absorptivity and the sensitivity of Sandell's index were calculated and equal to 8.51×103 l/mol.cm and0.0239 µg/cm2, respectively. The values of detection limit (LOD), quantification limit (LOQ) and the range of relative error percentage were estimated and found to be 0.0050, 0.0166 µg/mL and -0.374% to -0.147%, respectively. The precision (represented by RSD) was also calculated and found to be in the range ±0.037 to ±0.28. The suggested procedure was useful successfully to the assay of phenylephrine hydrochloride in injection, drops and syrups. No interferences were observed from common additives found in pharmaceutical preparations. The yellow color of the product was highly stable and did not show a significant change in absorbance up to 60 min

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Spectrophotometric Determination of Phenylephrine Hydrochloride by Coupling with Diazotized 2- Aminobenzothiazole

Cited by 6 publications

References 19 publications

Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms

Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms

Determination of Phenylephrine-HCl Using Conductometric Titration Method

Development of Spectrophotometric Method to Assay Phenylephrine Hydrochloride in Pure and in its Pharmaceutical Forms Using Diazotized Sulphanilic Acid

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