Spectrophotometric Determination of Procainamide by Charge-Transfer Complexation

Abstract

A simple and sensitive spectrophotometric method has been developed for the determination of procainamide (PA) in pure and pharmaceutical formulations. The proposed method is based on the formation of charge-transfer complex between the drug and 1-chloro-2, 4-dinitrobenzene (CDNB). PA in the presence of CDNB formed yellowish red colored complex, which showed a maximum absorbance at 410 nm. The limit of detection and quantitation were 0.1183 mg/ml and 0.3940 mg/ml respectively. The influence of commonly used excipients on the determination of PA was studied.