Spectrophotometric determination of Salbutamol sulphate by coupling with diazotized 2,4-dinitroaniline

Saleem, M.; AL-Mtwaiti, S. M.; Al-Ramadhani, Salih T.

doi:10.33899/edusj.2013.89814

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Because of salbutamol's role in doping, its determination has become a widely discussed topic. Until now, many analytical methods for the determination of salbutamol have been reported, such as high-performance liquid chromatography [10,11], immunoassay [12,13], spectrophotometry [14,15], capillary electrophoresis, colorimetry [16,17], electrochemiluminescence [18,19] and electrochemical determination [20,21]. However, most of these methods require various derivatization steps as well as more sophisticated procedures such as efficient extraction purification or a combination of different detection methods before the final analysis.…”

Section: Introductionmentioning

confidence: 99%

Development of CuO nanoparticles modified electrochemical sensor for detection of salbutamol

Koc Delice,

Ak Azem,

Ozdemir

et al. 2024

Mater. Res. Express

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Metal oxide structures are being utilized in an increasing variety of applications. This study used cyclic and differential pulse voltammetry technique to investigate the possible utilization copper oxide (CuO) nanoparticle modified carbon paste electrode (CPE) for the redox reactions of salbutamol (SAL). The electrochemical performance of the SAL analyte in a complex matrix environment in Ventolin was evaluated in order to assess the appropriateness of the proposed sensor in a real sample environment. CuO nanoparticles were produced via a straightforward, cost effective and efficient sol-gel method and characterization studies of synthesized CuO nanoparticles were performed by scanning electron microscopy, X-ray Diffraction (XRD) and X-ray photoelectron spectroscopy. The synthesized CuO nanoparticles had a spherical shape and particle size was found to be 74 nm. Crystal size of the CuO particles was calculated to be 21.79 nm by using the Debye-Scherrer equation. Under optimal conditions, differential pulse voltammetry demosrated a linear response in the 50 nM to 100 µM range, with a salbutamol detection limit of 50 nM (S/N=3). The SAL concentration (R2 = 0.9971) was found to have a good correlation coefficient. The reproducibility of the biosensor was investigated and evaluated with a relative standard deviation of 3% (n=8). The storage stability of CuO modified CPE for two weeks was evaluated based on the response of DP current measured at intervals every two days. According to the measurement results, the modified electrode exhibited good stability and reproducibility while maintaining 80% of its stability. It is also a rapid and dependable sensor candidate with a measurement time of approximately 20 seconds. The developed electrode has been utilized successfully to determine doping material with improved performance.

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