Spectrophotometric Determination of Some Cephalosporins in Bulk and in Pharmaceutical Formulations

Roopa, K. P.; Jayanna, B.K.

doi:10.1080/22297928.2016.1191970

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…In continuation of our work on the spectrophotometric determination of organic compounds of pharmaceutical importance [25][26][27][28][29][30][31][32], the present paper reports elegant methods for the spectrophotometric determination of solifenacin succinate using N-bromosuccinimide (NBS).…”

Section: Articlesmentioning

confidence: 99%

Determination of Solifenacin Succinate in Pure and Pharmaceutical Dosage forms by Spectrophotometry

Papanna¹,

Basavaiah

Gowda³

et al. 2021

J Anal Chem

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Four simple, precise and sensitive visible spectrophotometric methods were developed for the determination of solifenacin succinate in pure and pharmaceutical dosage forms. The proposed methods were based on the estimation of unreacted N-bromosuccinimide (NBS) with four dyes, namely, amaranth, safranin, aniline blue and rhodamine B, by the drug oxidation by known excess of NBS at laboratory temperature. Beer-Lambert's law revealed good correlation in the concentration ranges of 10-70, 20-80, 30-80, and 10-50 μg/mL for methods A, B, C and D, respectively. The developed methods were successfully applied to the determination of solifenacin succinate in commercially available dosage forms. Statistical comparison of the results showed insignificant difference between the proposed methods and reference method. The proposed methods offered the advantages of simplicity and economy that can be applied without the need for expensive instrumentation and reagents in quality control analysis.

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Section: Articlesmentioning

confidence: 99%

Determination of Solifenacin Succinate in Pure and Pharmaceutical Dosage forms by Spectrophotometry

Papanna¹,

Basavaiah

Gowda³

et al. 2021

J Anal Chem

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“…It has excellent coloring properties that stabilize dyes in acidic and alkaline media, absorbs visible frequencies of light being colored compounds from the yellow to red range, in addition to color stability, and is a non-toxic and environmentally friendly compound. Dyes are usually large aromatic molecules consisting of many connected rings attached to vinyl groups, which are more stable [7]- [9]. Most azo dyes are synthesized by diazotization of a primary amine followed by conjugation with one or more electron-rich nucleophiles such as amines or hydroxyl [10], [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of New Azo Dye Derived from Sulfamethaxolevia Diazonium Reaction and Study its Abilityas an Acid-base Indicator

Falih,

Mahdi,

Jasim

et al. 2024

Al-Mustansiriyah Journal of Science

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Background: Most azo dyes are synthesized by diazotization of a primary amine, followed by conjugation with one or more electron-rich nucleophiles. Objective: This study presents the synthesis of a new azocompound by converting sulfamethoxazole to a diazonium salt. Methods: via reaction with hydrochloric acid and sodium nitrite at temperatures between 0 and 5 °C, the resulting salt is then coupled with a 4-methoxyphenol reagent in alkaline medium at the above temperatures to produce an azodye given the IUPAC name of (4-((2-hydroxy-5-methoxyphenyl)diazenyl)-N-(5-methylisoxazol-3yl)benzenesulfonamide). The azo dye precipitate was purified by crystallization methods using a solvent mixture of ethanol water. Characterization was done using different analytical methods such as IR, UV-Vis and H1-NMR in addition to measurements of physical properties. Results: The reddish-pink azo compound gave a maximum absorbance of 495 nm. Acid-base titrimetric analysis was conducted to examine the chemical indicator properties of the azo dye. Clear color differences were obtained between two spaces in the pH range 2-12, where a reddishpink color was obtained in the basic medium and a yellow color in the acidic medium. Conclusions: A new azo dye successfully presented its properties as an indicator.

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“…Cefepime chemically 7--(2-aminothiazol-4-yl)-(z)methoxyiminoacetamido]-3-(1methylpyrrolidino)-methyl-3-cephem-4-carboxylate [1], as shown in figure 1. CFM is a third-generation cephalosporin bactericidal activity spectrum in vivoandin vitroagainstaerobic gram-negative and gram-positive micro-organisms [2,3], including penicillin resins, For the analysis of Tazo-bactam (TZB) in pharmaceutical preparations [4,5] and plasma [6] either alone or in combination with other products, various analytical methods such as spectrophotometry [7,8]HPLC8 [9] TLC [10] exist for the analysis of cefepime (CFM) and similarly different HPLC methods are available. Diazotization method inexpensive and very simple method, the Azo-dye it is very important families of dye, that contain -N=Nband [11,12].…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Estimation of Cefepime by using Batch, Cloud Point extraction and Flow Injection Analysis methods

2021

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New simple sensitive spectrophotometric methods are developed for determination of cefepime (CFM) in pure and Pharmaceutical Formulations. The first method conversion primary amine to azo-dye by react cefepime with sodium nitrite and hydrochloric acid followed by coupling with 2,6-dimethylphenol in alkaline medium to obtain a stable reddish-orange colored dye at λ max 515nm. The concentration ranges 2-50 μg / mL, Beer's law is obeyed, correlation coefficient was 0.9996, molar absorptivity was 0.826×10 4 L.mol -1 .cm -1 and the detection limit was 0.192 μg/mL. Cloud point extraction (CPE) second method to estimation a trace amount in aqueous solution product from diazotization and measuring with a UV-visible spectrophotometer at λ max 515 nm. The concentration range obeyed the Beer's law was 0.25-10 μg / mL, correlation coefficient was 0.9997, molar absorptivity was 1.169×10 5 L.mol -1 .cm -1 , detection limit was 0.027 μg/mL, Pre-concentration factor was 25 and Distribution coefficient(D) was 332.35. Last methods flow injection analysis it's simple for estimation the cefepime .The concentration ranges 1-150 μg / mL, Beer's law is obeyed, correlation coefficient was 0.9997, molar absorptivity was 0.341×10 4 L.mol -1 .cm -1 and the detection limit was 0.464μg/mL. The proposed methods were successfully, applied to the determination cefepime in pharmaceutical formulation.

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Spectrophotometric Determination of Some Cephalosporins in Bulk and in Pharmaceutical Formulations

Cited by 8 publications

References 15 publications

Determination of Solifenacin Succinate in Pure and Pharmaceutical Dosage forms by Spectrophotometry

Determination of Solifenacin Succinate in Pure and Pharmaceutical Dosage forms by Spectrophotometry

Synthesis and Characterization of New Azo Dye Derived from Sulfamethaxolevia Diazonium Reaction and Study its Abilityas an Acid-base Indicator

Spectroscopic Estimation of Cefepime by using Batch, Cloud Point extraction and Flow Injection Analysis methods

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