Spectrophotometric Determination of Some Chemotherapeutic Agents Using Acetyl Acetone

Abstract

Acetyl acetone is introduced as a new coupling agent for the spectrophotometric determination of some chemotherapeutic agents, such as metoclopramide, dapsone, p-aminobenzoic acid, and cisapride in both pure and dosage forms. The method is based on the diazo-coupling reaction of these chemotherapeutic agents with a new coupling agent, acetyl acetone, in an alkaline medium. The optimum reaction conditions and other analytical parameters are evaluated. The influence of the substrates commonly employed as excipients with these chemotherapeutic agents has been studied. The method is simple, rapid, and sensitive. The results obtained compare favorably with those obtained with other reference methods.

Application of potassium permanganate to spectrophotometric assay of metoclopramide hydrochloride in pharmaceuticals

“…Visible spectrophotometric methods based on diverse reactions have been proposed for the determination of MCP in pharmaceuticals [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. MCP is a good electron donor, and procedures based on charge-transfer complex formation reactions with π acceptors such as chloranil and bromanil [21] have been reported.…”

“…Extractive spectrophotometric procedures based on an ion-pair complexation reaction with bromothymol blue [22], Mo (V) and Co (II) thiocyanates [23], have also been proposed. Other visible spectrophotometric methods based on reactions with p-dimethylaminocinnamaldehyde [24], p-dimethylaminobenzaldehyde and β-naphthol [25], 8-anilino-1-naphthalene sulfonic acid, resorcinol and β-naphthol [26], naphthoquinone, hydroquinone and resorcinol [27], imipramine hydrochloride [28] benzoylacetone [29], aniline [30], dibenzoylmethane [31], acetyl acetone [32], chromotropic acid and MBTH, [33] dicarboxypropylrhodanine [34], resorcinol [35], 4-aminosalicylic acid [36], sodium 1,2-naphthoquinone-4 sulfonate [37], folin-ciocalteu [38], sodium vanadate [39], and ammonium metavanadate [40] are also found in the literature. Most of the above visible spectrophotometric methods suffer from one or another disadvantage such as the use of organic solvents [22][23][24][29][30][31][32] or expensive reagent [33], poor sensitivity [21,23,24,32,34,37,39,40], the use of a heating [21,30,37,39,40] or extraction step …”

Metoclopramide – nitrite reaction. Validation of its application to the spectrophotometric analysis of generic tablets

“…A large set of methods is founded on diazotization of the aryl primary amine of MCP with NaNO 2 in acidic medium and the formation of a colored dye by the coupling reaction between various coupling agents: sodium dibenzoilmetane [25]; p-dimethylaminocinnamaldehyde [26]; imipramine hydrochloride [27] diphenylamine [28] acetyl acetone [29] N-(1-naphthyl)-ethylenediamine [30] p-nitroaniline [31][32]and αnaphthylamine [33]. The main difficulty is that solutions of nitrite are unstable and have to be stored in the refrigerator and frequently replaced, and it is necessary to attach the diazo compound to molecules that confer stability.…”

Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations Using Three Different Spectrophotometric Methods

“…These spectrophotometric procedures include derivative spectrophotometric [19,20], UV spectrophotometric [21][22][23] and sequential injection spectrophotometric [24,25]. Several spectrophotometric methods based on diazo-coupling reaction [26][27][28][29][30][31][32][33][34][35][36], Schiff`s base reaction [36][37][38][39], ion-pair complex reaction [40,41], charge-transfer reaction [42,43] and redox reaction [44,45] were described. Also, spectrofluorimetric methods for MCP determination were suggested [46][47][48].…”