Spectrophotometric determination of some MAO inhibitors using 7,7,8,8-tetracyanoquinodimethane and iodine monochloride

Ibrahim, F.; Belal, F.; Hassan, Sayed M.; Aly, Fatma A.

doi:10.1016/0731-7085(91)80132-s

Cited by 10 publications

(3 citation statements)

References 13 publications

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“…6 Because of its pharmacological relevance, several analytical methods have been reported for the determination of INH either in pure and dosage forms or in biological fluids. Among these analytical methods, one can mention titration, [7][8][9][10][11] fluorometry, 12 spectrophotometry, [13][14][15][16][17][18][19][20][21][22][23] atomic absorption spectrometry, 24 chemiluminescence, 25,26 polarography, 27 high-performance liquid chromatography, [28][29][30][31][32][33][34] and capillary electrophoresis. 35 The room temperature FTIR and Raman spectra of neat crystalline INH were reported first by Gunasekaran et al, 36 which assumed the INH molecule to have C s symmetry.…”

Section: Introductionmentioning

confidence: 99%

“…Because of its pharmacological relevance, several analytical methods have been reported for the determination of INH either in pure and dosage forms or in biological fluids. Among these analytical methods, one can mention titration, − fluorometry, spectrophotometry, − atomic absorption spectrometry, chemiluminescence, , polarography, high-performance liquid chromatography, − and capillary electrophoresis …”

Section: Introductionmentioning

confidence: 99%

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Molecular Structure, Infrared Spectra, and Photochemistry of Isoniazid under Cryogenic Conditions

2009

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In this study, the structure, spectroscopy, and photochemistry of isoniazid (C6H7N3O, INH) were studied by low-temperature infrared spectroscopy and quantum chemistry calculations. According to DFT(B3LYP)/6-311++G(d,p) calculations, 12 minima were found on the potential energy surface of the molecule, corresponding to two cis conformers about the O=C-N-N axis (C1, C2) and one form trans about this axis (T), all being 4-fold degenerate by symmetry. The C1 conformer was predicted to be more stable than T and C2, by 20.4 and 22.6 kJ mol(-1), respectively. In consonance with these results, only C1 could be observed in low-temperature argon and xenon matrixes as well as in the neat glassy state prepared from the vapor of the compound at 70 degrees C. The C1 conformer was also found to be the constituting monomeric unit of the crystalline phase of INH produced from warming of the low-temperature neat amorphous state. The infrared spectra of INH in the different phases studied were fully assigned. After UV (lambda > 235 nm) irradiation of the matrix-isolated isoniazid, the compound was found to undergo photolysis through two different pathways: a Norris type I alpha-cleavage leading to production of isonicotinaldehyde and N2H2 and a concerted sigmatropic reaction with production of pyridine, CO and N2H2. The latter reaction was found to be nearly two times faster than the former in both argon and xenon matrixes. In addition, both reactions were found to be disfavored in a xenon matrix, which is in consonance with the involvement of (n, pi*) excited states in both photochemical processes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular Structure, Infrared Spectra, and Photochemistry of Isoniazid under Cryogenic Conditions

2009

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“…Literature survey shows that the methods used for assay of TCP-SO 4 are mainly for its evaluation in bulk biological fluids using HPLCelectrochemical detector (Rashid et al, 2013), determination in plasma using LC-MS/MS (KirchherrKühn-Velten, 2005), in vivo, in urine and pharmaceutical formulation using symmetry column (Aboul-Enein and Abou-Basha, 1996;Taavitsainen et al, 2001) and separation of TCP-SO 4 enantiomers (Aboul-Enein and Serignese, 1995;Spahn et al, 1992). Other methods for determination of TCP-SO 4 involves spectrophotometric methods Ibrahim et al, 1991;Knochen et al, 1989;Rizk et al, 2003), a conductometric method (GHANI et al, 2004), gas chromatographic methods (Aspeslet et al, 1992;BaileyBarron, 1980;Baker et al, 1985;Baselt et al, 1977;CrifasiLong, 1997;ValentineMiddleton, 2000), proton magnetic resonance (HannaLau-Cam, 1988) and an enzymatic assay for dextro or levo TCP-SO 4 in the brain (Fuentes et al, 1975). The chemical stability of pharmaceutical molecules is a matter of great concern as it affects the safety and efficacy of the drug product.…”

Section: Introductionmentioning

confidence: 99%

Validated, Ultra High Efficiency RP-HPLC and Stability Indicating Method for Determination of Tranylcypromines Sulphate in Bulk and in Tablet Dosage Forms

Ragab¹,

Saleh²,

Elhenawee³

et al. 2016

J App Pharm Sci

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Simple, sensitive, rapid and stability indicating ultra high efficiency RP-HPLC method was developed and validated for analysis of Tranylcypromine sulphate in bulk drug and in tablet dosage forms. Well-resolved peaks of target analyte and its degradation products were achieved on a Kinetex ® column (75 mm x 4.6 mm ID) 2.6 µm at 30 °C , using simple isocratic mobile phase of acetonitrile -orthophosphoric acid 0.1 % (10: 90, v/v). The flow rate was 1.0 mL/min and the detection was performed at 220 nm. The retention time of the drug was 2 min while for the reported method was 6.7 min. The method was validated according to International Conference on Harmonization (ICH) guidelines. Tranylcypromine was subjected to the stress conditions of hydrolytic acidic, basic, oxidative, and photolytic degradation. The assay was linear over the concentration range of 3-150 µg mL -1 and the correlation coefficient was 1. The RSD% of inter and intraday precision was less than 1 %. The % recoveries were found to be 100.58 % proved that the proposed method is sufficiently accurate and precise. The method distinctly separates the drug from its degradation products within 2 min and total run time of 8 min.

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Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation with molybdenum and thiocyanate

Mohamed

El-Dien

Khalil

et al. 2006

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Spectrophotometric determination of some MAO inhibitors using 7,7,8,8-tetracyanoquinodimethane and iodine monochloride

Cited by 10 publications

References 13 publications

Molecular Structure, Infrared Spectra, and Photochemistry of Isoniazid under Cryogenic Conditions

Molecular Structure, Infrared Spectra, and Photochemistry of Isoniazid under Cryogenic Conditions

Validated, Ultra High Efficiency RP-HPLC and Stability Indicating Method for Determination of Tranylcypromines Sulphate in Bulk and in Tablet Dosage Forms

Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation with molybdenum and thiocyanate

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