Spectrophotometric determination of Sulphamethoxazole Via Charge Transfer Complex Formation Reaction

Abstract

range of 2-60 μg ml-1 with molar absorptivity 3.675×10 3 L mol −1 cm −1. The limits of detection (LOD) and limit of quantitation (LOQ) were 0.371 and 1.236 μg ml-1 respectively. The accuracy and precision of the method were satisfactory; the average recovery % was 100.95 % and values of relative standard deviations ≤1.06 %. The stoichiometry of the reaction was studied, and the reaction mechanism was postulated. The proposed method was successfully applied to the determination of sulphamethoxazole in its pharmaceutical tablets and syrup with good accuracy and precisions.