Spectrophotometric method for determination of ranitidine hydrochloride in bulk and in pharmaceutical preparation using ninhydrin

Baker, Hutaf M.; Alsaoud, Hussam Ahmad; Abdel-Halim, Hamzeh M.

doi:10.5155/eurjchem.11.4.291-297.2002

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…An analytical comparison was performed in Table 6 to show the advanced sensitivity and efficiency of the suggested potentiometric modified sensors for the determination of RNT with other previously reported analytical techniques [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. The comparative results showed that the suggested modified sensors using metal oxide nanoparticles exhibited higher sensitivity over a wide concentration range than those reported by the previously developed sensors.…”

Section: Resultsmentioning

confidence: 99%

Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride

et al. 2022

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Two metal oxide nanoparticles, magnesium oxide nanoparticles (MgONPs) and aluminum oxide nanoparticles (Al2O3NPs), were synthesized from green sources, Salvia officials and Cuminum cyminum seed extract, respectively. These nanoparticles were used for construction of potentiometric enhancement sensors employed for the estimation of ranitidine hydrochloride (RNT) in authentic powder and commercial products. The electroactive substance ranitidine-phosphotungstate (RNT-PT) was formed by combining RNT with phosphotungstic acid (PTA) in the presence of plasticizing material o-nitrophenyloctyl ether (o-NPOE). The outcomes showed that the enhanced MgO and Al2O3 nanosensors behaved linearly across the concentration ranges 1.0 × 10−9–1.0 × 10−2 and 1.0 × 10−10–1.0 × 10−2 mol L−1, respectively. However, the conventional sensor (RNT-PT) displayed a linearity over 1.0 × 10−6–1.0 × 10−2 mol L−1. Least square equations were calculated as EmV = (54.1 ± 0.5) log (RNT) + 762.33, EmV = (58.6 ± 0.2) log (RNT) + 696.48, and EmV = (52.2 ± 0.7) log (RNT) + 756.76 for enriched nanometal oxides modified and conventional sensors, respectively. The correlation coefficients of regression equations were 0.9997, 0.9995, and 0.9992 for the above suggested sensors, respectively. The recorded results showed excellent sensitivity and selectivity of the modified nanometal oxide sensors for the quantification of the analyzed drug in its authentic samples and commercial products.

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Section: Resultsmentioning

confidence: 99%

Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride

et al. 2022

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“…In this research, a new spectrophotometric method for the determination of Cr (III) using ninhydrin was investigated, Ninhydrin in this research acts as chromogenic agent [12]. The ability of ninhydrin (a bidentate ligand) to function as an analytical reagent was the subject of some interesting and practical data presented in this work [13] [14] [15]. The chromogenic reagent in this procedure was ninhydrin.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Method for Determination of Chromium Ion in Aqueous Solution Using Ninhydrin

Baker¹,

Rahoomi²,

Abdel-Halim³

2022

AJAC

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A simple, precise, inexpensive and reproducible spectrophotometric method was investigated for the determination of chromium ion (III) in aqueous media, this method based on the formation of a complex between chromium ion (III) and ninhydrin, a deep greenish-violet colored product in the presence of potassium hydroxide was obtained. The absorption of this product was measured at λ max = 375 nm. The reaction proceeds quantitatively at room temperature. The linear calibration curve was constructed over range of (4.8 × 10 −4 -1.6 × 10 −2 ) mol/L of chromium ions with molar absorptivity of 2.90 × 10 2 and correlation coefficient R 2 = 0.9989. The calculated Sandell's sensitivity value is 0.179 µg/cm 2 , the limits of detection (LOD) and the limit of quantification (LOQ) are found to be 3.74 × 10 −5 and 1.24 × 10 −4 mol/L, respectively. The method was successfully applied for determination of the chromium ion in aqueous solution. The stoichiometry of the reactions was determined molar combining ratio of 1:2 between chromium and ninhydrin.

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Micro analysis ranitidine in pharmaceutical formation using CPE method coupling with spectrophotometric method

Hamran¹,

Khudhair²

2022

The 9th International Conference on Applied Science and Technology (Icast 2021)

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Spectrophotometric method for determination of ranitidine hydrochloride in bulk and in pharmaceutical preparation using ninhydrin

Cited by 3 publications

References 17 publications

Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride

Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride

Spectrophotometric Method for Determination of Chromium Ion in Aqueous Solution Using Ninhydrin

Micro analysis ranitidine in pharmaceutical formation using CPE method coupling with spectrophotometric method

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