Spectrophotometric method for the determination of verapamil hydrochloride in pharmaceutical formulations using N-bromosuccinimide as oxidant

Rahman, Nafisur; Azmi, Syed Najmul Hejaz

doi:10.1016/j.farmac.2004.02.008

Cited by 39 publications

(25 citation statements)

References 30 publications

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“…These methods involves two stages oxidation of the drug by NBS and the estimation of unconsumed NBS with Celestine blue (CB). Some drugs can be directly determined with NBS in acidic (30,31) or alkaline (32)(33)(34)(35) media and the color formed is determined spectrophotometrically. Potentiometric method involves the direct titration of drug with NBS in acidic medium is rare in the literature (36) .…”

Section: Cefprozilmentioning

confidence: 99%

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

2010

Egypt. J. Chem.

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WO SIMPLE, accurate spectrophotometric and potentiometric m methods were developed for the determination of cefprozil, dropropizine and tizanidine hydrochloride in their pharmaceutical preparations. The spectrophotometric method is based on the selective oxidation of cefprozil or tizanidine with N-bromosuccinimide in an alkaline medium to give an intense yellow product with a maximum absorption at 396 or 384 nm, respectively. The reaction conditions were studied and optimized. The reaction obeyed Beer's law over the concentration range 5-40 and 10-80 g ml -1 for cefprozil and tizanidine hydrochloride, respectively. The potentiometric method involves the direct titration of cefprozil and dropropizine with Nbromosuccinimide in sulphuric acid medium and the end point is determined potentiometrically using platinum electrode. Cefprozil and dropropizine can be determined quantitatively in the concentration range of 0.13-1.30 and 0.118-1.180 mg with recovery values of 98.46-100.77 and 99.58-100.85% and relative standard deviations 0.39-0.54 and 0.52-0.87% for cefprozil and dropropizine, respectively. The proposed methods are applied for the determination of these drugs in pure forms and in pharmaceutical preparations.

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Section: Cefprozilmentioning

confidence: 99%

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

2010

Egypt. J. Chem.

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“…Extractive spectrophotometric procedures are popular for their sensitivity in the assay of drugs and, therefore, ion-pair extractive spectrophotometry has received considerable attention for the quantitative determination of many pharmaceutical compounds. [15][16][17][18][19] The method is based on the formation of ionassociate between the cited drugs and methyl orange (MO), bromocresol green (BCG) and bromphenol blue (BPB) reagents. Different factors affecting these reactions are studied and established, then Beer's law is carried out.…”

Section: Cab N-[3-(dimethylamino)propyl]-n-(ethylamino)car-mentioning

confidence: 99%

Spectrophotometric Determination of Dopaminergic Drugs Used for Parkinson's Disease, Cabergoline and Ropinirole, in Pharmaceutical Preparations

Önal

Çağlar

2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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Cabergoline (CAB) and ropinirole hydrochloride (ROP) are dopamine agonists which are effective in improving motor function in Parkinson's disease. 1) CAB, N-[3-(dimethylamino)propyl]-N-(ethylamino)car-bonyl-6-(2-propenyl)ergoline-8b-carboxamide, a long acting predominantly D2 receptor agonist is effective as adjunct therapy in advanced Parkinson's disease and also as monotherapy in de novo patients.2,3) A few high-performance liquid chromatographic (HPLC) methods have been developed for the determination of CAB in plasma using electrochemical detection, 4) tandem mass spectrophotometry (TMS) 5-7) or triple-quadrupole mass spectrometry. 8) ROP, 4-[2-(dipropylamino)ethyl]-l,3-dihydro-2H-indol-2-one hydrochloride, is a specific D2 and D3 receptor non-ergoline dopamine agonist that is probably equally effective as L-dopa in mild, early Parkinson's disease.9) Very few HPLC methods in plasma were developed using ultraviolet, 10,11) electrochemical 12) or mass spectrometric 13) detection. Capillary zone electrophoresis was used for the determination of the dissociation constants of ROP and five structurally related impurities potentially formed during its synthesis and for separation and quantification of these substances.14)The present work aims to present a simple, rapid and sensitive method for the determination of cabergoline and ropinirole in tablets and can be used for the quality control and assurance of these drugs in industry. Extractive spectrophotometric procedures are popular for their sensitivity in the assay of drugs and, therefore, ion-pair extractive spectrophotometry has received considerable attention for the quantitative determination of many pharmaceutical compounds. [15][16][17][18][19] The method is based on the formation of ionassociate between the cited drugs and methyl orange (MO), bromocresol green (BCG) and bromphenol blue (BPB) reagents. Different factors affecting these reactions are studied and established, then Beer's law is carried out. The constructed calibration curves were utilized in determining the concentration of these drugs in tablets. These methods are very simple in application and less expensive in comparison to the other techniques. ExperimentalApparatus A Shimadzu UV-160 A UV-visible spectrophotometer with 1-cm matched glass cells was used for the absorbance measurements. pH measurements were determined using a WTW pH 526 digital pH meter, calibrated with pH 4.0 and 7.0 disodium hydrogen phosphate standard buffer solution.Reagents and Solutions Cabergoline and its pharmaceutical preparation (Cabaser ® ) containing 4 mg of cabergoline per tablet were kindly supplied by Pfizer (Istanbul, Turkey). Ropinirole hydrochloride and its pharmaceutical preparation (Requip ® ) containing 2 mg of ropinirole per tablet were kindly supplied by GlaxoSmithKline (Istanbul, Turkey). Analytical-reagent grade chemicals/reagents and bidistilled water were used throughout the work. MO, BCG and BPB were obtained from Merck (Darmstadt, Germany). Stock solutions of CAB and ROP (1 mg ml Ϫ1 (for ROP, c...

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“…N-Bromosuccinimide, due to its strong oxidation properties, has been extensively employed as a reagent in the analytical investigations of many organic compounds: phenothiazine derivatives, 12 nitrofurazone, 13 ranitidine, 14 verapamil 15 and prazosin hydrochlorides, 16 tertiary amines and ammonium salts 17 and some catecholamine derivatives. 18 The reaction of oxidation of olanzapine with NBS showed that the investigated drug is easily oxidized with NBS in acidic medium, giving the purple product of oxidation (λ = 532 nm).…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Olanzapine by Its Oxidation with N-Bromosuccinimide and Cerium(IV)sulfate

Krebs

Starczewska

Puzanowska-Tarasiewicz

et al. 2006

ANAL. SCI.

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Three simple spectrophotometric methods have been described for the assay of olanzapine in its pure and pharmaceutical formulations. The direct method (A) is based on the drug oxidation with excess of N-bromosuccinimide in acidic medium and the two indirect methods (B and C) are based on the oxidation of the drug with excess of Nbromosuccinimide and cerium(IV)sulfate, followed by the reaction of the unconsumed oxidants with celestine blue. The calibration graphs were linear over the range 10 -120 μg mL -1 (method A), 0.5 -6.0 μg mL -1 (method B) and 0.6 -3.0 μg mL -1 (method C). After validation, the proposed methods were successfully applied to assay of olanzapine in its commercial tablets with mean percentage recoveries of 101.23 ± 0.10, 96 ± 0.10 and 94 ± 0.04%. The mechanism of olanzapine oxidation with N-bromosuccinimide was also proposed.

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Spectrophotometric method for the determination of verapamil hydrochloride in pharmaceutical formulations using N-bromosuccinimide as oxidant

Cited by 39 publications

References 30 publications

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

Spectrophotometric Determination of Dopaminergic Drugs Used for Parkinson's Disease, Cabergoline and Ropinirole, in Pharmaceutical Preparations

Spectrophotometric Determination of Olanzapine by Its Oxidation with N-Bromosuccinimide and Cerium(IV)sulfate

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