Spectrophotometric methods for simultaneous estimation of rabeprazole sodium and aceclofenac from the combined capsule dosage form

Sawant, Ramesh L.; Hadawale, Sanket D.; Dhikale, Ganesh K.; Bansode, Charusheela A.; Tajane, Pravin S.

doi:10.4103/2229-4708.90362

Cited by 20 publications

(12 citation statements)

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“…Q-absorbance ratio method, a modified version of the simultaneous equation method, depends on the ratio of absorbance of a substance at two different wavelengths. One is the maximum wavelength of any one of two component and other is the wavelength of the iso-absorptive point [4,5]. This method is applicable for a combination of drugs which obeys Beer's law and the absorbance ratio at two wavelengths is a constant value which is independent of the path length and concentration.…”

Section: Q-absorbance Ratio Methodsmentioning

confidence: 99%

Different Ultraviolet Spectroscopic Methods: A Retrospective Study on Its Application From the Viewpoint of Analytical Chemistry

Mukherjee

Chakraborty

et al. 2021

Asian J Pharm Clin Res

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In routine practice, some simple and rapid analytical methods are needed for the assessment of formulations containing multiple elements, complex matrix system and for biotherapeutic products. There are several methods available for ultraviolet (UV) spectrophotometry that rely on the concept of absorbance difference, absorbance spectra, and additivity, also included in the list are simultaneous equation method, Q-absorbance ratio method, derivative spectrophotometry, ratio derivative spectra, successive ratio-derivative spectra, absorption and absorptivity factor method, and difference spectrophotometry along with multivariate chemometric methods. In this review, emphasis has been given to the theories, mathematical context, advantages, and disadvantages along with the vast applications of UV spectrophotometry. The findings further highlighted that for the analysis of drugs, UV spectrophotometry remains as one of the most simple, cheap, and promising option for routine practice in the field of pharmaceuticals.

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Section: Q-absorbance Ratio Methodsmentioning

confidence: 99%

Different Ultraviolet Spectroscopic Methods: A Retrospective Study on Its Application From the Viewpoint of Analytical Chemistry

Mukherjee

Chakraborty

et al. 2021

Asian J Pharm Clin Res

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“…The concentration of drugs SOF and VEL in sample solutions were determined by the simultaneous equation method 17 using the following formula:…”

Section: Fig 3: Overlay Spectra Of Sofosbuvir and Velpatasvirmentioning

confidence: 99%

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2021

IJPSR

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A simple, linear, precise, and economical UV spectrophotometric method has been developed for the simultaneous estimation of sofosbuvir and velpatasvir in the bulk and pharmaceutical dosage form. The standard stock solutions were prepared by using methanol as solvent. Estimation of sofosbuvir and velpatasvir was conducted by using a simultaneous equation method based on the measurement of Maximum absorbance at two wavelengths. The maximum absorbance was found at 261 nm for sofosbuvir and velpatasvir at 303 nm, respectively. The linearity was found in the concentration range of (5.0 μg/mL-30.0 μg/mL) for sofosbuvir and (2.5 μg/mL-20.0 μg/mL) for velpatasvir with correlation coefficient of 0.996 for sofosbuvir and 0.994 for velpatasvir, respectively. Regression equation for sofosbuvir and velpatasvir were y = 0.0198x -0.0061, y = 0.0225x + 0.029. The % accuracy was within the range of 98.04-101.70%, and precision (%RSD) was found to be < 2. The developed method was validated according to ICH guidelines and successfully applied for the assay of marketing formulations.

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“…The intra-day and the inter-day precision study was performed by preparing the dilution of 2.0 µg/ml, 2.5 µg/ml, 3.0 µg/ml for TH and 240 µg/ml, 300 µg/ml and 360 µg/ml for FLZ and from the respective stock solutions for both the drugs, respectively and recording their absorbance at 222 nm and 239 nm against 0.1N HCl as a blank. The absorbance of these concentrations was measured three times a day at regular intervals of one hour for intra-day and day1, day 2, and day 3 for inter-day study [17,18].…”

Section: Intra-day and Inter-day Precisionmentioning

confidence: 99%

New Developed and Validated Spectroscopic Method for the Simultaneous Estimation of Terbinafine Hydrochloride and Fluconazole

Thakur

Kumar²

2020

Int J Pharm Pharm Sci

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Objective: A new, simple, precise, accurate, and reproducible method or simultaneous equation method was developed and validated for the simultaneous estimation of terbinafine hydrochloride (TH) and fluconazole (FLZ) in pure form. Methods: Simultaneous estimation of terbinafine hydrochloride and fluconazole was estimated by the ultraviolet (UV) spectrophotometry method. The method was based on the measurement of absorbance at two wavelengths 222 nm and 239 nm, of terbinafine hydrochloride and fluconazole in 0.1N HCl respectively. Results: Calibration curves terbinafine hydrochloride and fluconazole were found to be linear in the concentration ranges of 0.5-3.0 μg/ml and 80-400 μg/ml, respectively, with their correlation coefficient values (R2) 0.999 and 0.998. LOD and LOQ of TH were found to be 0.067, 0.203 at 222 nm and 0.175, 0.531 at 239 nm, similarly for FLZ; 31.089, 94.210 at 222 nm and 94.380, 286.00 at 239 nm respectively. In the precision study, the % RSD value was found within limits (%). The percentage recovery at various concentration levels varied from 98.50 % to 103.96 % for TH and 97.27 % to 103.83 % for FLZ confirming that the expected method is accurate. Conclusion: It could be concluded from the results obtained in the present study that this method for simultaneous estimation of TH and FLZ in pure is simple, precise, and economical. The proposed method can be applied successfully for the simultaneous estimation of TH and FLZ in the pure and pharmaceutical dosage form.

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Spectrophotometric methods for simultaneous estimation of rabeprazole sodium and aceclofenac from the combined capsule dosage form

Cited by 20 publications

References 1 publication

Different Ultraviolet Spectroscopic Methods: A Retrospective Study on Its Application From the Viewpoint of Analytical Chemistry

Different Ultraviolet Spectroscopic Methods: A Retrospective Study on Its Application From the Viewpoint of Analytical Chemistry

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New Developed and Validated Spectroscopic Method for the Simultaneous Estimation of Terbinafine Hydrochloride and Fluconazole

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