Spectrophotometric multicomponent analysis of a mixture of chlorhexidine hydrochloride and lidocaine hydrochloride in pharmaceutical formulation using derivative spectrophotometry and partial least-squares multivariate calibration

Dönmez, Özlem Aksu; Bozdoğan, Abdürrezzak; Kunt, Gönül; Dıv, Y.

doi:10.1134/s1061934810010077

Cited by 22 publications

(14 citation statements)

References 31 publications

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“…Outrossim, no caso do uso indevido ele pode causar excitação do sistema nervoso central (SNC), depressão e reação alérgica [25][26][27]. Destarte, o desenvolvimento de um método eficiente e rápido da detecção da sua presença e concentração segue sendo uma tarefa atual ainda hoje [28][29][30][31][32].…”

Section: Discussionunclassified

A detecção eletroquímica da lidocaína sobre o oxihidróxido de cobalto trivalente. Uma possibilidade teórica a ser avaliada

Tkach

Ivanushko

Lukanova

et al. 2018

Rev. colomb. cienc. quim. farm.

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ResumoO comportamento eletroquímico da lidocaína durante a sua eletrooxidação sobre o oxihidróxido de cobalto trivalente em meio levemente básico, realizada para fins eletroanalíticos, foi avaliado do ponto de vista mecanístico matemático. Da análise foi feita uma conclusão acerca do desempenho do CoO(OH) como modificador de elétrodo na eletrooxidação da lidocaína in vivo e in vitro. Foi, outrossim, verificada a possibilidade da realização das instabilidades oscilatória e monotônica no sistema.Palavras-chave: segurança de medicação, elétrodos quimicamente modificados, lidocaína, oxihidróxido de cobalto, estado estacionário estável. Summary Lidocaine CoO(OH)-assisted electrochemical determination. A theoretical possibility to be evaluatedThe electrochemical behavior of lidocaine during its electrooxidation over trivalent cobalt oxyhydroxide in lightly alkaline medium, realized for electroanalytical purposes, was evaluated from the mechanistic mathematical point of view. From Artigo de pesquisa científica / http: //dx.doi.org/10.15446/rcciquifa.v47n1.70659

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Section: Discussionunclassified

A detecção eletroquímica da lidocaína sobre o oxihidróxido de cobalto trivalente. Uma possibilidade teórica a ser avaliada

Tkach

Ivanushko

Lukanova

et al. 2018

Rev. colomb. cienc. quim. farm.

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“…Derivative spectrophotometry has been extensively used in the determination of drugs in multicomponent systems having overlapping spectra, which eliminates interference from matrix formulation by using the zero-crossing techniques [40][41][42]. Ratio-spectra derivative spectrophotometric method is another useful technique for the estimation of drugs in their mixtures [43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Validated derivative and ratio derivative spectrophotometric methods for the simultaneous determination of levocetirizine dihydrochloride and ambroxol hydrochloride in pharmaceutical dosage form

Ali

Ismail

Elgohary

2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…To date, the most frequently method for LH determination is the high-performance liquid chromatography (HPLC) due to its high sensitivity and excellent selectivity ( 1 - 7 ). Other methods such as gas chromatography ( 8 ), electrophoresis ( 9 - 11 ), spectrophotometry ( 12 , 13 ), and atomic absorption spectrometry (indirect method) ( 14 ) have also been developed. Most of these methods are expensive, time consuming, suffer from extensive pretreatment steps and use toxic solvents and reagents.…”

Section: Introductionmentioning

confidence: 99%

Electro-Oxidation Mechanism and Direct Square-Wave Voltammetric Determination of Lidocaine With a Carbon-Paste Electrode

Rahbar

Ramezani

Babapour

2015

Jundishapur J Nat Pharm Prod

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Background: Lidocaine hydrochloride (LH) is one of the most extensively used local anesthetics and peripheral analgesics. Availability of a simple and sensitive assay method for this analyte in pharmaceutical preparations as well as development of new voltammetric detectors that can be applied in chromatographic systems for determination of this analyte in biological samples are of great importance. Objectives: In this study, a square-wave voltammetric (SWV) determination of LH at a bare carbon-paste electrode (CPE) was reported. Moreover, the oxidation mechanism for LH molecule at this electrode was investigated. Materials and Methods:The SW voltammogram of LH solution at CPE showed a well-defined peak between +0.80 and +0.88 V depending on a scan rate in potassium nitrate (KNO 3 ) solution. Different chemical and instrumental parameters influencing the voltammetric response, such as the pH level and scan rate were optimized for LH determination. Results: A linear range of 8.0 -1000.0 μmol L -1 (r 2 = 0.999) was obtained. The limit of detection (LOD) was 0.29 μmol L -1 . The relative standard deviations of 2.1% obtained for 0.8 800 μmol L -1 solution of LH indicated a reasonable reproducibility of the method. Conclusions:The results of this study show that LH in different pharmaceutical preparations could be determined with good reliability. In addition, the results reveal that the equal numbers of electrons and protons are involved in the oxidation of LH and the irreversible oxidation of an analyte was performed via amine groups of LH molecule.

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Spectrophotometric multicomponent analysis of a mixture of chlorhexidine hydrochloride and lidocaine hydrochloride in pharmaceutical formulation using derivative spectrophotometry and partial least-squares multivariate calibration

Cited by 22 publications

References 31 publications

A detecção eletroquímica da lidocaína sobre o oxihidróxido de cobalto trivalente. Uma possibilidade teórica a ser avaliada

A detecção eletroquímica da lidocaína sobre o oxihidróxido de cobalto trivalente. Uma possibilidade teórica a ser avaliada

Validated derivative and ratio derivative spectrophotometric methods for the simultaneous determination of levocetirizine dihydrochloride and ambroxol hydrochloride in pharmaceutical dosage form

Electro-Oxidation Mechanism and Direct Square-Wave Voltammetric Determination of Lidocaine With a Carbon-Paste Electrode

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