Spectrophotometric resolution of ternary mixtures of salicylaldehyde, 3-hydroxybenzaldehyde and 4-hydroxybenzaldehyde by the derivative ratio spectrum-zero crossing method

Nevado, J. J. Berzas; Cabanillas, Carmen Guiberteau; Salinas, F.

doi:10.1016/0039-9140(92)80179-h

Cited by 148 publications

(23 citation statements)

References 10 publications

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“…It is required first to optimize the following factors: concentration of the divisor, Δ λ to compute the first derivative, smoothing and wavelengths at zero-crossing. [19][20][21][22] SFB was estimated in presence of LDP by DR 1 using the normalized spectrum of LDP as divisor as shown in Figure 5. The derivative of the constant LDP LDP′ is zero.…”

Section: First Derivative Of Ratio Spectra (Dr 1 )mentioning

confidence: 99%

Simultaneous determination of the brand new two-drug combination for the treatment of hepatitis C: Sofosbuvir/ledipasvir using smart spectrophotometric methods manipulating ratio spectra

Eissa

2017

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Section: First Derivative Of Ratio Spectra (Dr 1 )mentioning

confidence: 99%

Simultaneous determination of the brand new two-drug combination for the treatment of hepatitis C: Sofosbuvir/ledipasvir using smart spectrophotometric methods manipulating ratio spectra

Eissa

2017

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…This method was developed by Salinas et al [18]. Berzas Nevado et al extended this method to resolving ternary mixtures [19]. …”

Section: Introductionmentioning

confidence: 99%

Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin

Walash

Rizk

Sheribah

et al. 2011

Chemistry Central Journal

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Three simple and rapid spectrophotometric methods were developed for detection and trace determination of benzophenone (the main impurity) in phenytoin bulk powder and pharmaceutical formulations. The first method, zero-crossing first derivative spectrophotometry, depends on measuring the first derivative trough values at 257.6 nm for benzophenone. The second method, zero-crossing third derivative spectrophotometry, depends on measuring the third derivative peak values at 263.2 nm. The third method, ratio first derivative spectrophotometry, depends on measuring the peak amplitudes of the first derivative of the ratio spectra (the spectra of benzophenone divided by the spectrum of 5.0 μg/mL phenytoin solution) at 272 nm. The calibration graphs were linear over the range of 1-10 μg/mL. The detection limits of the first and the third derivative methods were found to be 0.04 μg/mL and 0.11 μg/mL and the quantitation limits were 0.13 μg/mL and 0.34 μg/mL, respectively, while for the ratio derivative method, the detection limit was 0.06 μg/mL and the quantitation limit was 0.18 μg/mL. The proposed methods were applied successfully to the assay of the studied drug in phenytoin bulk powder and certain pharmaceutical preparations. The results were statistically compared to those obtained using a polarographic method and were found to be in good agreement.

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“…The direct UV spectropho tometric method presents several problems including the spectral bands of both OLM-HCT and ZOF-HCT overlap. The ratio spectra derivative spectro photometric (DD 1 ) method [17][18][19][20] has been found to be useful for the estimation of drugs in their mix tures. The use of the derivative spectrophotometric method for resolving a mixture with overlapped spec tra produces a considerable loss of accuracy and sensi tivity.…”

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confidence: 99%

Simultaneous determination and validation of some binary mixtures of antihypertensive drugs using ratio derivative spectrophotometric method

2014

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Ratio derivative spectrophotometric technique is presented for the rapid, accurate and precise simultaneous determination of olmesartan medoxomil (OLM), hydrochlorothiazide (HCT), and zofenopril (ZOF) as well as HCT binary mixtures in their dosage forms. First derivative of the ratio spectra (DD1) by measurements using different amplitudes was used and calibration graphs were established for 0.5-12 mg/mL HCT and 0.5-20 mg/mL OLM and ZOF. This method depends on first derivative of the ratio spectra by divi sion of the absorption spectrum of the binary mixture by a standard spectrum of one of the components and then calculating the first derivative of the ratio spectrum. The first derivative of the ratio amplitudes at 250.4 and 291.5 nm for OLM, 250.4 and 298.1 nm for ZOF and 231.8, 332.2, 232.3 and 280.4 nm for HCT were selected for the determination. The proposed methods were successfully applied for determining of both drug combinations (ZOF-HCT and OLM-HCT) in their synthetic mixtures and in pharmaceutical dosage forms. The described procedures are extensively validated, non destructive and do not require any separation steps.

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Spectrophotometric resolution of ternary mixtures of salicylaldehyde, 3-hydroxybenzaldehyde and 4-hydroxybenzaldehyde by the derivative ratio spectrum-zero crossing method

Cited by 148 publications

References 10 publications

Simultaneous determination of the brand new two-drug combination for the treatment of hepatitis C: Sofosbuvir/ledipasvir using smart spectrophotometric methods manipulating ratio spectra

Simultaneous determination of the brand new two-drug combination for the treatment of hepatitis C: Sofosbuvir/ledipasvir using smart spectrophotometric methods manipulating ratio spectra

Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin

Simultaneous determination and validation of some binary mixtures of antihypertensive drugs using ratio derivative spectrophotometric method

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