Spectrophotometry: Pharmaceutical Applications

Photocatalytic activity of Fe/Ti-based compounds obtained from ferro-titaniferous mineral sands via a simple soft chemistry route

“…In addition, the absorption of electromagnetic radiation of the iron-caffeine coordination complex has been reported near to the maximum absorption band of pure caffeine at 272 nm [30]. The formation of such coordination complex can resemble to an acid-base reaction where caffeine (Lewis base ligand) donates a pair of electrons to the metal ion Fe +2 (Lewis acid) to form the metal-ligand bond [31]. Thus, the iron-caffeine complex can also be considered as a charge-transfer complex, where absorption of radiation is due to an electronic transition from the donor to the corresponding orbital of the acceptor so that the associated molar absorptivity (ε) is high compared to that of molecules that exhibit π, σ and n electron transitions [31].…”

“…The formation of such coordination complex can resemble to an acid-base reaction where caffeine (Lewis base ligand) donates a pair of electrons to the metal ion Fe +2 (Lewis acid) to form the metal-ligand bond [31]. Thus, the iron-caffeine complex can also be considered as a charge-transfer complex, where absorption of radiation is due to an electronic transition from the donor to the corresponding orbital of the acceptor so that the associated molar absorptivity (ε) is high compared to that of molecules that exhibit π, σ and n electron transitions [31]. As such, the increased absorbance values at 272 nm observed in Figure 9 could be associated to the increased light absorption of the newly formed iron-caffeine complex, which molar absorptivity has been reported larger (>1x10 4 M -1 cm -1 ) than that of pristine caffeine (>9.74x10 3 M -1 cm -1 ) [32].…”

New spectrophotometric microdetermination of carbapenem antibiotics derivatives in pharmaceutical formulations

“…Drug quality control is a branch of analytical chemistry with a wide impact on public health; thus, the development of reliable, quick and accurate methods for active-ingredient determination is notably important. Spectrophotometric methods are the most commonly used techniques and continue to enjoy wide popularity [16][17][18]. The common availability of the instrumentation, simplicity of the procedures, and speed, precision and accuracy of the technique make spectrophotometric methods attractive.…”

Determination and Assay of Some Antineoplastic Agents in Pure Form and in their Pharmaceutical Preparation

“…Most of the methods use sophisticated instruments like HPLC [11], TLC [12], colorimetry [13], infrared spectrophotometry [14] and other techniques. Herein, we reported a simple titrimetric method for assay of some antineoplastic drugs i.e.…”