Spectroscopic analysis of charge transfer complex formation between neuroleptics and iodine.

Abstract

Molecular interactions between iodine and various neuroleptics were investigated by UV/Vis spectroscopy. Iodine was found to form charge transfer complexes in a 1:1 stoichiometry and of n-sigma type with these molecules. The values of the formation constants Kc of these iodinated complexes indicate a strong donor-acceptor interaction. These drugs can therefore be expected to interfere with thyroid metabolism.

Electrocatalytic oxidation of sulfide and electrochemical behavior of chloropromazine based on organic–inorganic hybrid nanocomposite

“…The tolerance limit was defined as the maximum concentration of the interfering substance that caused an error less than 3% for determination of sulfide. The results showed, the peak current of the proposed electrode is not significantly affected by all conventional cations (Na +, Li + , K + , Ca 2+ , Mg 2+ , Pb 2+ and Cd 2+ ), anions (SO 4 2− , IO 3 − , PO 4 3− , I − , Cl − , Br − , F − , IO 4 − and BrO 3 − ) when their concentration are 50 times greater than that of sulfide ion. But SO 3 2− and S 2 O 4 2− at the same concentration mentioned above show interfering effect and increase the catalytic peak current of sulfide.…”

“…It is widely used as a therapeutic agent for treating various mental and personality disorders, in the prevention of vomit spasms and as an intravenous antihypertensive. One of the common properties of phenothiazine and its derivatives is that they are easily oxidized and lose a single electron to become cation radicals [2][3][4] which are very active and can react with a number of substances [5][6][7][8][9]. It was found that cation radicals are colored and stable in acidic media.…”

A novel electrocatalyst with high sensitivity in detecting glutathione reduced by 2-hydroxypropyl-β-cyclodextrin enveloped 10-methylphenothiazine

“…So they are easily oxidized and lost electrons to become very active cation radicals [12][13][14][15][16][17][18][19] . Therefore, an interesting work is presented to study the reactions of phenothiazine with some living matter [13,17,18] .…”

“…11 So they are easily oxidized and lose electrons to become very active cation radicals. [12][13][14][15][16][17][18][19] Therefore, an interesting work is presented to study the reactions of phenothiazine with some living matter. 13,17,18 In recent years, researchers have developed a lot of methods to quantify the glutathione in biological samples.…”

Electrocatalytic and Analytical Responses of 10-Methylphenothiazine Toward Reduced Glutathione

“…One of the common properties of phenothiazine and its derivatives is that they are easily oxidized and lose a single electron to become cation radicals, [4][5][6] which are very active. [7][8][9][10][11][12] Therefore, the research on reactions of phenothiazine cation radicals, especially the reactions between phenothiazine and some living substances, is very intriguing.…”