Spectroscopic Analysis of Iodinated Molecular Complexs of Thiazole and Thiazoline Derivatives

Buxeraud, Jacques; Lagorce, Jean-fran腔is; Jambut-Absil, Anne-Catherine; Raby, C

doi:10.3987/com-89-4975

Cited by 8 publications

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“…24 in which RS − denotes for deprotonated PTU and RSSR is its dimer after oxidation by iodine. The product may be an adduct between RSSR and iodine 12,13 which is electroactive at the electrode surface. A sharp decrease in the characteristic absorption peaks of I 3 − (290 and 355 nm) 25 upon addition of PTU confirms the reaction between the two species (Fig.…”

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confidence: 99%

“…8 The interaction between heterocyclic thiols (such as PTU and methimazole) and iodine has been the subject of some researches. [9][10][11][12][13][14] The formation of an adduct between the thiols (in disulfide form) and iodine was proposed. In this work, a detailed voltammetric study of the oxidation of PTU by iodine was conducted in order to investigate the kinetics of the reaction, which is significant from a biochemical view.…”

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confidence: 99%

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A Kinetic Study on Electrooxidation of Propyl-Thiouracil: An Anti-Hyperthyroid Drug by Potassium Iodide

Jalali

Riahi

Nematollahi

2013

J. Electrochem. Soc.

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The kinetics of the redox reaction between anti-hyperthyroid drug, propylthiouracil (PTU), and iodine was studied by cyclic voltammetry. Iodide is the mediator in the electrocatalytic oxidation of PTU at the surface of a platinum electrode. The second order rate constant (k obs ) increased with pH in a pH range of 2 to 6. The reaction rate was also dependent on the concentration ratio of PTU to iodide. A simulation software was used to interpret the observations and to calculate k obs at different pHs.

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