Spectroscopic and mechanistic analysis of the interaction between Jack bean urease and polypseudorotaxane fabricated with bis-thiolated poly(ethylene glycol) and α-cyclodextrin

Zhao, Jun; Yu, Chun-Liu; Fang, Wei; Jiduan, Lin; Chen, Guo; Wang, Xiaoqin

doi:10.1016/j.colsurfb.2019.01.011

Cited by 7 publications

(1 citation statement)

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“…The linear relationship between the hydrogel mass loss and the protein release profile confirmed that the erosion of the hydrogel matrix is the key factor for drug release. Such systems that are based on α-cyclodextrin and poly(ethylene glycol) have found wide applications as a drug carriers for low molar mass drugs; nucleic acids; or proteins, such as insulin [88,89], lysozyme [90], human immunoglobulin G [91], antibody-based drugs (such as omalizumab, palivizumab, panitumumab, and ranibizumab [92]), α-chymotrypsin [93], Jack bean urease [94], silver sulfadiazine [95], and siRNA [96]. Recently, systems with nucleobase-terminated PEG were synthesized to improve the rheological properties and prolong drug release.…”

Section: α-Cyclodextrin/linear Polymer-based Polypseudorotaxane Hydromentioning

confidence: 99%

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

2019

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Supramolecular hydrogels that are based on inclusion complexes between α-cyclodextrin and (co)polymers have gained significant attention over the last decade. They are formed via dynamic noncovalent bonds, such as host-guest interactions and hydrogen bonds, between various building blocks. In contrast to typical chemical crosslinking (covalent linkages), supramolecular crosslinking is a type of physical interaction that is characterized by great flexibility and it can be used with ease to create a variety of "smart" hydrogels. Supramolecular hydrogels based on the self-assembly of polypseudorotaxanes formed by a polymer chain "guest" and α-cyclodextrin "host" are promising materials for a wide range of applications. α-cyclodextrin-based polypseudorotaxane hydrogels are an attractive platform for engineering novel functional materials due to their excellent biocompatibility, thixotropic nature, and reversible and stimuli-responsiveness properties. The aim of this review is to provide an overview of the current progress in the chemistry and methods of designing and creating α-cyclodextrin-based supramolecular polypseudorotaxane hydrogels. In the described systems, the guests are (co)polymer chains with various architectures or polymeric nanoparticles. The potential applications of such supramolecular hydrogels are also described.

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