2015
DOI: 10.1016/j.saa.2014.10.036
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Spectroscopic and molecular docking studies on the interaction of the drug olanzapine with calf thymus DNA

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Cited by 23 publications
(13 citation statements)
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“…Although 1,5-benzodiazepines [1] are compounds with interesting biological properties, [2] they can be considered orphan molecules, in the sense that their pharmacological potential has not been fully explored. [3] Marketed drugs belonging to this family are Clobazam (Figure 1) with anxiolytic and anti-convulsant properties, [4] Olanzapine, an antipsychotic for the treatment of schizophrenia and bipolar disorder, [5,6] and Nevirapine, a dipyridodiazepinone, a reverse transcriptase inhibitor currently used to treat HIV-1 infection and AIDS. [7] Although the existence of compounds as important as Olanzapine and Nevirapine seems to be in contradiction with our use of orphan molecules, it should be noted that they are also bioisosteres of 1,4benzodiazepines where a benzene has been replaced by a thiophene or a pyridine and, as such, their biological properties cannot be ascribed exclusively to the 1,5-benzodiazepine skeleton.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although 1,5-benzodiazepines [1] are compounds with interesting biological properties, [2] they can be considered orphan molecules, in the sense that their pharmacological potential has not been fully explored. [3] Marketed drugs belonging to this family are Clobazam (Figure 1) with anxiolytic and anti-convulsant properties, [4] Olanzapine, an antipsychotic for the treatment of schizophrenia and bipolar disorder, [5,6] and Nevirapine, a dipyridodiazepinone, a reverse transcriptase inhibitor currently used to treat HIV-1 infection and AIDS. [7] Although the existence of compounds as important as Olanzapine and Nevirapine seems to be in contradiction with our use of orphan molecules, it should be noted that they are also bioisosteres of 1,4benzodiazepines where a benzene has been replaced by a thiophene or a pyridine and, as such, their biological properties cannot be ascribed exclusively to the 1,5-benzodiazepine skeleton.…”
Section: Introductionmentioning
confidence: 99%
“…1,5-Benzodiazepine-2-ones(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) represented as the most stable tautomer a (see Scheme 1). Preparation of 1,5-benzodiazepine-2-ones (a is the imino tautomer and b the enamino tautomer).…”
mentioning
confidence: 99%
“…The ctDNA in the B conformation shows two bands in the CD spectrum: a positive band due to base stacking (∼278 nm) and a negative one owing to the DNA right-handed helicity (∼247 nm) [46]. Fig.…”
Section: Binding Of Lycl To Calf Thymus Dna Ctdnamentioning
confidence: 92%
“…Circular dichroism spectroscopy, CD, is useful in monitoring changes in DNA morphology caused by its interactions with other substances [46]. The ctDNA in the B conformation shows two bands in the CD spectrum: a positive band due to base stacking (∼278 nm) and a negative one owing to the DNA right-handed helicity (∼247 nm) [46].…”
Section: Binding Of Lycl To Calf Thymus Dna Ctdnamentioning
confidence: 99%
“…DNA purity was checked using absorption of DNA in 260 nm (A 260 ) and 280 nm (A 280 ). e A 260 /A 280 ratio was 1.85, indicating that the ct-DNA was sufficiently pure and protein free [17,18]. Stock solution of WTN (5 × 10 − 3 M in ddH 2 O) was prepared immediately before experiments due to instability.…”
Section: Methodsmentioning
confidence: 99%