Spectroscopic and physicochemical studies on the interactions of reversible H+/K+-ATPase inhibitors with phospholipid bilayers

Reid, David G.; MacLachlan, Lesley K.; Mitchell, Robert E.; Graham, M. J.; Raw, M. J.; Smith, Paul A.

doi:10.1016/0005-2736(90)90432-n

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Cited by 5 publications

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“…2B) indicates that the molecular motions of the drug, which appear to be axially symmetrical, give rise to a 30‐fold reduction of the static quadrupolar interaction (∼175 kHz). From previous studies on related compounds, it is assumed that the principal rotational axis of the drug is coincident with the CO bond and parallel with the bilayer normal 16. Although the conformation of the molecule in DMPC membranes cannot be determined unambiguously, it was assumed as a starting point for the analysis that the drug adopts a planar, extended structure in which the angle between CD bond and the rotational axis is 60°.…”

Section: Resultsmentioning

confidence: 99%