Spectroscopic and structural characterization of the charge-transfer interaction of N,N′-bis-alkyl derivatives of 1,4,6,8-naphthalenediimide with chloranilic and picric acids

Refat, Moamen S.; Ahmed, Hamdy A.; Grabchev, Ivo; El-Zayat, Lamia

doi:10.1016/j.saa.2007.10.007

Cited by 21 publications

(6 citation statements)

References 32 publications

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“…1-3. This ratio could be related to the stric hindrance effect of the MBz molecule 46 . The formation constants, K f (L mol -1 ) and extinction coefficients,  (L mol -1 cm -1 ), of the CT complexes, were calculated using the absorbance values obtained by adding different MBz concentrations to a certain concentration of CA or PA, and by applying the modified Benesi-Hildebrand equation 44 for a 1:1 molar ratio Eq.…”

Section: Fig 5: Effect Of Acceptor Volume On the Formation Of Mbz Ctmentioning

confidence: 99%

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2019

IJPSR

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This article presents the development of a direct, simple and sensitive spectrophotometric method for the quantitative analysis of mebendazole (MBz), an anthelmintic medication in its pure and pharmaceutical forms. The method is based on the charge transfer (CT) interactions between MBz, an electron donor, and chloranilic acid (CA), 3,5dinitrosalicylic acid (DNSA), and picric acid (PA), (all of which are acceptors). The products of the CT reactions exhibit new absorption bands at 409 and 310 nm for CA and DNSA in methanol, respectively, and at 402 nm for PA in dichloroethane. Following the optimization of the experimental conditions, linearity ranges for MBz concentrations of 2.00-120, 1.00-40.0 and 2.00-25.0 µg mL-1 were achieved for CA-MBz, DNSA-MBz, and PA-MBz, respectively. Furthermore, the limits of detection (LOD) and quantification (LOQ) were calculated. The method was used to determine the MBz concentrations of tablets with good accuracy and precision and without interference from common tablet excipients. INTRODUCTION: Mebendazole (MBz), i.e., methyl [5-benzol-1H-benzoimidazole-2-yl] carbamate Scheme 1, is a broad spectrum anthelmintic drug widely used against hookworm, pinworm, roundworm, tapeworm, threadworm and mixed infestations. Furthermore, MBz is widely used against gastrointestinal helminths in both humans and animals 1, 2. The most common global diseases are helminthic, and they cause a variety of serious health problems and impact child growth by causing anemia and other nutritional deficiencies 3. Thus, the World Health Organization (WHO) categorize MBz as an essential medicine in its capacity as a single-dose treatment for helminthic infections 4 .

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Section: Fig 5: Effect Of Acceptor Volume On the Formation Of Mbz Ctmentioning

confidence: 99%

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2019

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“…Stoichiometry of the CT complexes. 18,19 Molar ratio and Job's continuous variation methods are applied in order to determine the suitable ratio between ALP drug with DDQ or p-CLA reagents. Figures 5 and 6 shows that the interaction between this drug and reagents occurs in equimolar basis, i.e.…”

Section: 17mentioning

confidence: 99%

Spectrophotometric Determination of Allopurinol Drug in Tablets: Spectroscopic Characterization of the Solid CT Complexes

Refat¹,

Fathi²

2010

Bulletin of the Korean Chemical Society

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Spectrophotometric micro determination of allopurinol (ALP) via charge-transfer formation is described. This includes the utility of some π-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 3,6-dichloro-2,5-dihydroxy-p-benzoquinone (p-CLA) for estimation of ALP drug (act as è-donor). These reactions are applied for determination of ALP in its pharmaceutical preparations coming from different companies. Elucidation of the chemical structure of the solid CT complexes formed via reaction between drugs under study and π-acceptors, using elemental analyses (C, H, N), I. R., 1 H NMR and mass spectrometry.

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“…Reported methods for analysis of many drugs and charge transfer complex studies are studied mostly by direct UV-spectrophotometry [17][18][19][20][21][22][23][24][25] , colourimetry 26 and HPLC 27 . And also, our previous works showed that the EDA complexes have good non-linear optical properties and electrical conductivities [28][29][30] .…”

Section: Introductionmentioning

confidence: 99%

"Synthesis and Charge Transfer Complex Studies of Carbazole Substituted Pyridopyrimidine With Some ?-Acceptors "

2017

RJC

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Carbazole Substituted Pyridopyrimidine (CSPP) was synthesized and Charge transfer complexes with some acceptors such as tetracyanoquinomethane (TCNQ) and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) have been studied spectrophotometrically in acetonitrile at 21 o C. The stoichiometries of the complexes were found to be 1:1 ratio by the Job method between donor and acceptors with the maximum absorption band at a wavelength of 715 nm for DDQ and 593 nm for TCNQ. The formation constants of the complexes were determined by Benesi-Hildebrand equation. The thermodynamic parameters were calculated by Van't Hoff equations and found spontaneous and exothermic.

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Spectroscopic and structural characterization of the charge-transfer interaction of N,N′-bis-alkyl derivatives of 1,4,6,8-naphthalenediimide with chloranilic and picric acids

Cited by 21 publications

References 32 publications

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Spectrophotometric Determination of Allopurinol Drug in Tablets: Spectroscopic Characterization of the Solid CT Complexes

"Synthesis and Charge Transfer Complex Studies of Carbazole Substituted Pyridopyrimidine With Some ?-Acceptors "

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