Spectroscopic characterization and molecular modeling of novel palladium(II) complexes with carbazates and hydrazides

Sousa, Luana M.; Corbi, Pedro P.; Formiga, André Luiz Barboza; Lancellotti, Marcelo; Marzano, Ivana Marques; Pereira-Maia, Elene C.; Poelhsitz, Gustavo Von; Guerra, Wendell

doi:10.1016/j.molstruc.2015.05.012

Cited by 27 publications

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References 37 publications

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“…Two intense bands between 1085 and 1045 cm − 1 are attributable to the presence of two unidentate perchlorate ions [37]. Hydrazides show characteristic absorptions between 3332 and 3150 cm − 1 which are attributable to the NH 2 and NH groups [22,23]. In all complexes studied, the bands originating from NH 2 group showed considerable shift as compared to the free ligands.…”

Section: Resultsmentioning

confidence: 89%

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Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies

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Marzano

Jaimes

et al. 2017

Journal of Inorganic Biochemistry

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Five new copper(II) complexes of the type [Cu(NO)(NN)(ClO)], in which NO=4-fluorophenoxyacetic acid hydrazide (4-FH) or 4-nitrobenzoic hydrazide (4-NH) and NN=1,10-phenanthroline (phen), 4-4'-dimethoxy-2-2'-bipyridine (dmb) or 2,2-bipyridine (bipy) were synthesized and characterized using various spectroscopic methods. The X-ray structural analysis of one representative compound indicates that the geometry around the copper ion is distorted octahedron, in which the ion is coordinated to hydrazide via the terminal nitrogen and the carbonyl oxygen, and to heterocyclic bases via their two nitrogen atoms. Two perchlorate anions occupy the apical positions, completing the coordination sphere. The cytotoxic activity of compounds was investigated in three tumor cell lines (K562, MDA-MB-231 and MCF-7). Concerning K562 cell line, the complexes with 1,10-phenanthroline exhibit high cytotoxic activity and are more active than carboplatin, free ligands and [Cu(phen)]. Considering the cytotoxicity results, further investigations for the compounds [Cu(4-FH)(phen)(ClO)] I and [Cu(4-NH)(phen)(ClO)]∙HO III were performed. Flow cytometric analysis revealed that these complexes induce apoptotic cell death in MDA-MB-231 cell line and bind to DNA with K values of 4.38×10 and 2.62×10, respectively. These compounds were also evaluated against wild type Mycobacterium tuberculosis (ATCC 27294) and exhibited antimycobacterial activity, displayed MIC values lower than those of the corresponding free ligands.

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Section: Resultsmentioning

confidence: 89%

“…This class of compounds has the ability to readily coordinate to many transition metals. Therefore, several hydrazide complexes have been synthesized and characterized [22,23]. Some of these compounds exhibit remarkable biological properties, mainly antimycobacterial and antitumoral [24][25][26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies

Paixão

Marzano

Jaimes

et al. 2017

Journal of Inorganic Biochemistry

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“…The complex crystallized in the P21/c space group and the asymmetric part of the unit cell is presented in Figure 3 For similar Pd(II) and Pt(II) compounds reported in the literature [57][58][59][60][61][62] the trans isomers were predicted by DFT calculations to be the most stable geometry, with the exception of the Pt(II) complexes with 4-methoxybenzylcarbazate, benzyl carbazate and 3-methoxybenzoic acid hydrazide 63 , in which the cis isomers are suggested. This feature indicates that other factors such as steric hindrance, ligand basicity as well as intermolecular interactions may be responsible for the additional stabilization of such system in comparison to cis-coordinated complexes.…”

Section: Single Crystal X-ray Diffractionmentioning

confidence: 62%

Transition metal complexes with ibuprofen hydrazide

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Section: Conclusãomentioning

confidence: 99%

Síntese, caracterização e estudos biológicos envolvendo complexos de cobre(II) contendo hidrazidas e ligantes N,N-doadores

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À Deus pela oportunidade que me foi concedida. À minha família pelo apoio e paciência, principalmente a minha mãe por me confortar e me ajudar nos momentos de dificuldade.Ao meu orientador Wendell Guerra, pela oportunidade, confiança, amizade, dedicação e competência profissional ao longo desses anos. À minha grande mestra, amiga e coorientadora Silvana Guilardi, pelo apoio, dedicação, ensinamentos, incentivo e paciência. Aos professores Marcos Pivatto (UFU), Pedro Ivo da Silva Maia (UFTM), Victor Deflon (IQSC-USP), Javier Ellena (IFSC-USP), Sérgio de Albuquerque (FCFRP-USP), Ana Maria da Costa Ferreira (USP), Fernando Pavan (UNESP), Elene Cristina Pereira Maia (UFMG) e Françoise Vasconcelos Botelho (UFU) e aos pesquisadores Zumira Aparecida Carneiro (FCFRP-USP), Ivana M. Marzano (UFMG) e Edgar Lizarazo (UFMG) pelas valiosas contribuições durante o desenvolvimento deste trabalho. Aos membros da banca Carlos A. Oliveira (UFU), Gustavo Von Poelhsitz (UFU), Edson Nossol (UFU), Heveline Silva (UFMG) e Priscila P. S. Caldeira (CEFET-MG) por terem acolhido o convite para avaliar esse trabalho e por suas valiosas sugestões e contribuições.

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Spectroscopic characterization and molecular modeling of novel palladium(II) complexes with carbazates and hydrazides

Cited by 27 publications

References 37 publications

Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies

Novel copper(II) complexes with hydrazides and heterocyclic bases: Synthesis, structure and biological studies

Transition metal complexes with ibuprofen hydrazide

Síntese, caracterização e estudos biológicos envolvendo complexos de cobre(II) contendo hidrazidas e ligantes N,N-doadores

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