Spectroscopic characterization, antimicrobial activity and molecular docking study of novel azo-imine functionalized sulphamethoxazoles

Abstract

Sulfamethoxazolyl-azo-imine derivatives (1, 2a-f) have been examined against gram positive bacteria, B. subtillis and gram negative E. coli and have found effective selectively on B. subtillis. Some of them also show antiviral activity against HSV-1Finfection. The structures of the compounds are supported by different spectroscopic data and single crystal X-ray structure of 2c. The compounds have been docked in the DHPS protein cavity to examine their binding strength and 2c shows highest binding strength.

Antimicrobial sulphonamide azo dyes

“…The dipole moments of all the sulphonamide azo dyes were determined by the solvent perturbation method; the excited‐state dipole moments (μe) were greater than the ground‐state dipole moments (μg). Thus, the asymmetric and planar structure of 59 is different from the structures of 60 and 61 in the excited state …”

Idiosyncatic recognition of Zn2+ and CN− using pyrazolyl-hydroxy-coumarin scaffold and live cell imaging: depiction of luminescent Zn(ii)-metallocryptand

“…Schiff bases with fluorogenic components such as carbazole, 9,10 quinoline, 11,12 rhodamine, 13,14 naphthyl, 15,16 pyrenyl, 17,18 fluorenyl, 19,20 and diformyl 21,22 influence the emission energy, intensity, pattern, and the molecules might serve as sensitive detectors of ions/molecules. Fluorogenic units of Coumarin derivatives 23–25 are beneficial for their diverse pharmacological properties, low toxicity, and interesting photophysical responses to analytes.…”