Spectroscopic Characterization of Omeprazole and Its Salts

Vrbanec, Tomislav; Šket, Primož; Merzel, Franci; Smrkolj, Matej; Grdadolnik, Jože

doi:10.1155/2017/6505706

Cited by 8 publications

(7 citation statements)

References 23 publications

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“…Raman bands for omeprazole and its salt forms have been previously assigned in literature. [ 40 ] CH and NH deformation, and CH stretching is present in omeprazole at 1587 cm −1 ; however, this band is lacking in omeprazole magnesium. Likewise, CH and NH symmetric stretching band is found on omeprazole at 1189 cm −1 but is lacking on omeprazole magnesium.…”

Section: Resultsmentioning

confidence: 95%

Raman spectroscopy detects adulterated counter‐ions in pharmaceuticals

Fuini¹,

Reimers²,

Hudspeth³

et al. 2022

J Raman Spectroscopy

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Raman spectroscopy provides accurate and cost‐effective quality control of pharmaceuticals, which is essential for maintaining the confidence of dispensing physicians and patient's adherence to therapeutic regimens. For drug salts that contain a counter‐ion, the active pharmaceutical ingredient and counter‐ion combination is optimized for the intended therapeutic effect. Drug salts with multiple alternative counter‐ions are developed, dosed, and regulated independently and case study one demonstrates how an adulterated medication can contain a different counter‐ion than the label claim. Three additional case studies are performed that showcase how Raman spectroscopy can be applied as a cost‐effective alternative detection technique of both label claim drug and counter‐ion when compared to more commonly used HPLC‐UV methods.

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Section: Resultsmentioning

confidence: 95%

Raman spectroscopy detects adulterated counter‐ions in pharmaceuticals

Fuini¹,

Reimers²,

Hudspeth³

et al. 2022

J Raman Spectroscopy

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show abstract

“…Additionally, some peaks disappeared, which may be due to non-covalent interactions. Many researchers have previously reported attenuation, broadening, shifting and appearing/disappearing of Raman bands in cocrystals/salts spectra [ 68 , 69 , 70 , 71 , 72 ]. Based on literature data for cocrystals/salts, it is suggested that LEV-PTH and LEV-CFA interact with each other, which is the requirement for successful preparation of cocrystal/salt.…”

Section: Resultsmentioning

confidence: 99%

Levofloxacin Cocrystal/Salt with Phthalimide and Caffeic Acid as Promising Solid-State Approach to Improve Antimicrobial Efficiency

et al. 2022

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To overcome the issue of multidrug resistant (MDR) microbes, the exploration of ways to improve the antimicrobial efficiency of existing antibiotics is one of the promising approaches. In search of synthons with higher efficiency, in current investigations, cocrystal and amorphous salt of levofloxacin hemihydrate (LEV) were developed with phthalimide (PTH) and caffeic acid (CFA). New materials were characterized with the help of FT-IR, Raman spectroscopy, powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Shifting, attenuation, appearance/disappearance and broadening of bands were observed in the FT-IR and Raman spectra of the materials as evidence of the required product. The PXRD diffraction pattern observed for LEV-PTH indicated cocrystal while halo diffractogram of LEV-CFA revealed amorphous nature. DSC/TG analysis confirmed the hydrated nature of the cocrystal/salt. The dissolution rate and antimicrobial activity against selected strains, K.pneumonia, E. coli and S. typhi of parent drug and the new material were compared. The zone of inhibition (ZI) observed for 5 µg LEV-PTH was 30.4 + 0.36 (K. pneumonia), 26.33 + 0.35 (E. coli) and 30.03 + 0.25 mm (S. typhi) while LEV-CFA salt (5 µg) against the same strains inhibited 33.96 ± 0.25, 31.66 ± 0.35 and 27.93 ± 0.40 mm, respectively. These novel formulations enhance the dissolution rate as well as antibacterial efficiency and are expected to be potent against MDR bacterial strains.

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“…Absorption bands at 1423 cm −1 , 1181 cm −1 , and 1013 cm −1 are attributable to the pyridine group. High-intensity bands characteristic of S=O stretching vibrations occur at 978–381 cm −1 [ 21 , 22 ]. The IR spectrum obtained for the pure omeprazole powder and the various brands exhibited absorption bands around the aforementioned wavenumbers ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Physicochemical Equivalence and Quality Assessment of Various Brands of Gastro-Resistant Omeprazole Capsules in the Kumasi Metropolis

Osei

Boakye

Bayor

et al. 2022

The Scientific World Journal

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The proliferation of counterfeit and poor-quality drugs is a major public health problem, especially in developing countries such as Ghana where there are inadequate resources to effectively monitor their prevalence. Most of these drugs, which are counterfeited, are drugs, which are in high demand and will reap huge profits for the unscrupulous people who engage in such activities. The introduction of Omeprazole as one of the first-line therapies in the management of peptic and duodenal ulcers in the treatment guidelines of Ghana has resulted in many generics being introduced onto the market. The pharmaceutical quality of fifteen randomly sampled Omeprazole capsule brands in the Kumasi metropolis was assessed using the innovator brand as a comparator to confirm their suitability for patient use and to provide data for drug regulatory agencies in Ghana concerning poor quality omeprazole brands. All the sampled brands complied with the official specifications for identification with good primary and secondary packaging characteristics. Ninety-four (94%) of the sampled brands passed the uniformity of weight test. All the brands (n = 16) representing 100% passed the disintegration tests. Sixty percent (60%) of the sampled brands passed the drug content test. Ten brands (66.7%) met the specification for in vitro dissolution test. From f2 analysis, the dissolution profiles of only five brands (31%) were similar to that of the reference brand which indicated that they could be used interchangeably in clinical practice. Conclusively, ten out of the fifteen sampled brands were of good quality and only five could be used as a substitute for the innovator. Thus, regulatory agencies will need to strengthen their postmarket surveillance to ensure that generic brands of good quality are allowed onto the market.

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Spectroscopic Characterization of Omeprazole and Its Salts

Cited by 8 publications

References 23 publications

Raman spectroscopy detects adulterated counter‐ions in pharmaceuticals

Raman spectroscopy detects adulterated counter‐ions in pharmaceuticals

Levofloxacin Cocrystal/Salt with Phthalimide and Caffeic Acid as Promising Solid-State Approach to Improve Antimicrobial Efficiency

Physicochemical Equivalence and Quality Assessment of Various Brands of Gastro-Resistant Omeprazole Capsules in the Kumasi Metropolis

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