Spectroscopic investigation on formation and growth of mineralized nanohydroxyapatite for bone tissue engineering applications

Gopi, D.; Nithiya, S.; Shinyjoy, E.; Kavitha, L.

doi:10.1016/j.saa.2012.02.069

Cited by 67 publications

(44 citation statements)

References 25 publications

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“…1415-1421 and 875-878 cm -1 are assigned to CO 3 2-(asymmetric stretching ν 3 and out of plane bending ν 2 the last) [21], originated from the interactions of HAP with CO 2 absorbed by the samples from the atmospheric air. In the samples calcined at 300 o C these bands are attenuated.…”

Section: Resultsmentioning

confidence: 99%

Low Crystallinity Nanohydroxyapatite Prepared at Room Temperature

Mocanu¹,

Balint²,

Garbo³

et al. 2017

Studia UBB Chemia

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ABSTRACT. In order to obtain a low crystalline nanohydrxyapatite (HAP), suitable for biomedical application, a new synthesis procedure was developed, based on the aqueous precipitation method, at room temperature, without any additives. Accordingly, lyophilized HAP powders, both calcined and non calcined, were prepared, and characterized by XRD, TEM and AFM imaging, FTIR spectroscopy, zeta potential and BET measurements. The results confirmed HAP as the only phase present. The high porosity of this nanomaterial is attained. The nanoparticle size and shape as well as the crystallinity degree of the obtained HAP samples were also determined.

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Section: Resultsmentioning

confidence: 99%

Low Crystallinity Nanohydroxyapatite Prepared at Room Temperature

Mocanu¹,

Balint²,

Garbo³

et al. 2017

Studia UBB Chemia

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“…Consequently, a white precipitate was formed and was washed gently with double distilled water to remove the residual template and dried at 80 C for 12 h. The obtained powder was then calcinated in a muffle furnace at 900 C for 2 h. The mechanism for the formation of nanosized HAP spheres, rods, and fibers by surfactant-assisted microwave irradiation method is shown in Fig. 6.…”

Section: Microwave Irradiation Methodsmentioning

confidence: 99%

“…To synthesis Sr, Mg, and Zn co-substituted n-HAP for improved biomedical applications, 0.05 M of CaCl 2 Á 4H 2 O, 1 wt% SrCl 2 Á 6H 2 O, 1 wt% MgCl 2 Á 6H 2 O, and 0.25 wt% ZnCl 2 were mixed with 0.5 wt% of amino acid-glycine one by one, under constant stirring for about 1 h [80]. Further, 0.03 M (NH 4 ) 2 HPO 4 was added slowly to the above mixture and stirred for 12 h. The pH of the above mixture was adjusted to 9, 10, and 11 using required amount of NaOH solution.…”

Section: Synthesis Of Mineralized N-hapmentioning

confidence: 99%

“…Gopi et al [80] have also successfully synthesized the Sr, Mg, and Zn co-substituted n-HAP using glycine as a chelating agent by freezing at 2 C. The presence of glycine plays a great role in the control of the mineralized n-HAP by forming calcium glycinate complexes. The effect of pH on the crystallinity, size, and morphology of as-synthesized minerals substituted n-HAP was studied in detail [80].…”

Section: Synthesis Of Minerals Substituted N-hapmentioning

confidence: 99%

“…The effect of pH on the crystallinity, size, and morphology of as-synthesized minerals substituted n-HAP was studied in detail [80]. At pH 10, the mineralized HAP particles were of nanosized and without any agglomeration as shown in Fig.…”

Section: Synthesis Of Minerals Substituted N-hapmentioning

confidence: 99%

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Synthesis of Pure and Substituted Hydroxyapatite Nanoparticles by Cost Effective Facile Methods

Gopi¹,

Kavitha²,

Rajeswari³

2015

Handbook of Nanoparticles

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Bioceramics are the materials which can enhance the quality and longevity of human life. Hydroxyapatite (HAP) is a readily considered bioceramic material for artificial bone substitution in biomedical field due to its compositional resemblance to the bone mineral and very good biocompatiblity. Recently, HAP has attracted significant interest in drug delivery and bone tissue engineering applications. The human cortical bone consists of biological HAP which is found within collagen as nanodimensional crystalline aggregates. There has been enormous effort in developing bioactive synthetic ceramics that could closely mimic the fine and complex structure of human bone. Though HAP is highly biocompatible and bioactive, it possesses poor mechanical properties. In order to overcome this drawback, attempts are made toward the synthesis of mineralized HAP. Several methodologies have been investigated and developed for the synthesis of pure and substituted HAP. Modern research deals with novel HAP nanostructure formulations with properties closer to those of living bone, aiming at improved and more effective biomedical applications. This chapter presents the facile and cost-effective synthesis methods of pure and substituted HAP nanoparticles such as sol-gel approach, hydrothermal techniques, etc., toward effective biomedical applications.

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