Spectroscopic Investigations for Photo Stability of Diclofenac Sodium Complexed with Hydroxypropyl-beta-Cyclodextrin

Nemani, Shubhada Chandrasekhar; Sadheeshkumar, V.; Sivakumar, A.

doi:10.7324/japs.2016.60414

Cited by 13 publications

(5 citation statements)

References 7 publications

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“…Therefore, peaks at 1454.84 cm -1 , 1510.91 cm -1 , and 1557.15 cm -1 also supported aromatic ring presence in DFS. This is in accordance with the FTIR report on the investigation of Diclofenac sodium done in the literature [40].…”

Section: Resultssupporting

confidence: 93%

Tailored Basella Alba Mucilage-Based Bipolymeric Hydrogel Beads for Controlled Release of Diclofenac Sodium

CHOWDHURY,

KUMAR DE

2023

Int J App Pharm

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Objective: The present investigation aims to convert the underutilized Basella alba mucilage (BAM) into a smart carrier by formulating its bipolymeric hydrogel beads for the controlled release of Diclofenac sodium (DFS). Methods: At first, mucilage from the stem and fruits of Basella alba was extracted, isolated, and evaluated. Basella alba mucilage was chemically modified to its carboxymethyl derivative to improve its physicochemical properties. Single and bipolymeric hydrogel beads of carboxymethylated Basella alba mucilage (CBAM) and Sodium carboxymethyl cellulose (SCMC) were formulated by the Ionotropic gelation method using aluminium chloride (AlCl3) as a cross-linking agent. A four-factor I-optimal response surface design was used to optimize the formulations. Drug and excipient compatibility was studied by Fourier transform infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) study. Scanning electron microscopy (SEM) was done to reveal the surface morphology. In vitro release of the drug in phosphate buffer (pH 6.8) and acidic buffer (pH 1.2) were compared for all the formulations. The effect of various formulation parameters on the release of the drug was studied, and the best-fitting model for release kinetics was determined. Results: The degree of carboxymethylation was found to be 0.565±0.05. The bipolymeric beads were found to release 14% drug in 2 h in acidic media, minimize the release of the drug in the stomach to avoid the harsh effects of DFS and then provide controlled release in the intestine, releasing 80-90% of the drug in 10 h. The release kinetics followed the Hixon Crowell model, which suggests an erosion of the matrix to release the drug. Conclusion: The bipolymeric hydrogel beads of tailored Basella alba mucilage were found to control the release of Diclofenac sodium.

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Section: Resultssupporting

confidence: 93%

Tailored Basella Alba Mucilage-Based Bipolymeric Hydrogel Beads for Controlled Release of Diclofenac Sodium

CHOWDHURY,

KUMAR DE

2023

Int J App Pharm

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“…Sodium diclofenac was complexed with hydroxypropyl-b-CD and the subsequent physic-chemical characterization was performed in order to evaluate drug photo-stability. The results demonstrated that the photochemical degradation rate of the complexed drug was significantly reduced when an optimal 4:1 host:guest ratio was used (Manikandan et al, 2016). Rhein, a major metabolite of the prodrug diacerein is used in the treatment of osteoarthritis and diabetic nephropathy.…”

Section: Cyclodextrins As Drugs Stabilizersmentioning

confidence: 99%

Photosensitive drugs: a review on their photoprotection by liposomes and cyclodextrins

et al. 2017

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Nowadays, an exciting challenge in the drug chemistry and technology research is represented by the development of methods aimed to protect molecular integrity and therapeutic activity of drugs from effects of light. The photostability characterization is ruled by ICH (The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use), which releases details throughout basic protocols of stability tests to be performed on new medicinal products for human use. The definition of suitable photoprotective systems is fundamental for pharmaceutical manufacturing and for human healthy as well, since light exposure may affect either drugs or drug formulations giving rise even to allergenic or mutagenic by-products. Here, we summarize and discuss the recent studies on the formulation of photosensitive drugs into supramolecular systems, capable of entrapping the molecules in a hollow of their structure by weak noncovalent interactions and protecting them from light. The best known supramolecular matrices belong to the 'auto-assembled' structures, of which liposomes are the most representative, and the 'host-guest' systems, of which cyclodextrins represent the most common 'host' counterpart. A relevant number of papers concerning the use of both liposomes and cyclodextrins as photoprotection systems for drugs has been published over the last 20 years, demonstrating that this topic captures interest in an increasing number of researchers.

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“…NSAIDs are inhibiting these lysosomal enzymes by alleviating the lysosomal membrane. As we reported earlier, in-vitro anti-inflammatory activity was carried out by Human Red Blood Cell (HRBC) membrane stabilization method (n=4) using Diclofenac as standard [ 25 , 26 ]. The percentage of hemolysis was calculated by assuming the hemolysis produced in the presence of distilled water at 100%.…”

Section: Methodsmentioning

confidence: 99%

Pro- and Anti-Inflammatory Cytokine Expression Levels in Macrophages; An Approach to Develop Indazolpyridin-methanones as Novel Inflammation Medication

Srivastava

Shah

Sivakumar

et al. 2020

AIAAMC

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Background: Indented to develop novel (E)-Benzylidene-indazolpyridin methanones (Cpd-1-10) as effective anti-inflammatory agents, a molecular-based therapeutic investigation executed in order to measure the druggability possibilities of these compounds. Objectives: To determine pro-inflammatory and anti-inflammatory interleukin levels in J77A.1 macrophages, the TNF-α, IL-1β, IL-6 and IL-10 serum levels measured by ELISA method. Method: Their cytotoxicity effect against breast cancer cell lines found excellent and an extended anticancer study ensured that these compounds are also alternative therapeutic agents against breast cancer. In fact, COX-2 seems to be associated with cancers and atypical developments in the duodenal tract. A competitive ELISA based COX-2 inhibition assay was done. To validate the inhibitory potentials and to get more insight into the interaction of COX-2 with Cpd1-10, molecular docking was performed. Results: Briefly, the COX-2 inhibitory relative activity was found to be in between the range of 80-92 % (Diclofenac showed 84 %, IC50 0.95 µM). Conclusion: Among all the tested cancer cell lines, the anti-cancer effect on breast cancer was exceptional for the most active compounds Cpd5 and Cpd9.

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Spectroscopic Investigations for Photo Stability of Diclofenac Sodium Complexed with Hydroxypropyl-beta-Cyclodextrin

Cited by 13 publications

References 7 publications

Tailored Basella Alba Mucilage-Based Bipolymeric Hydrogel Beads for Controlled Release of Diclofenac Sodium

Tailored Basella Alba Mucilage-Based Bipolymeric Hydrogel Beads for Controlled Release of Diclofenac Sodium

Photosensitive drugs: a review on their photoprotection by liposomes and cyclodextrins

Pro- and Anti-Inflammatory Cytokine Expression Levels in Macrophages; An Approach to Develop Indazolpyridin-methanones as Novel Inflammation Medication

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