Spectroscopic investigations of the interactions of tramadol hydrochloride and 5-azacytidine drugs with human serum albumin and human hemoglobin proteins

Probing the binding interaction of human serum albumin with three bioactive constituents of Eriobotrta japonica leaves: Spectroscopic and molecular modeling approaches

“…This finding indicated that CRA/MA/TA bound with the amino acid residues of the main polypeptide chain of the protein and disrupted the hydrogen bond networks. CD results were generally expressed in terms of mean residue ellipticity (MRE) in deg cm 2 dmol À1 according to the following equation [38,39]:…”

Nanostructured products of the drug theophylline caused by charge transfer interactions and a binary solvent system: Morphology and nanometry

“…During the last decade, considerable efforts have focused on the interactions between drugs and acceptors both in the solid state and in solution. Such interactions play crucial roles in many processes; therefore, understanding these interactions is important for understanding the drug-receptor binding and the drug's mechanism of action as well as obtaining quantitative estimates of the drugs [10][11][12][13][14][15][16][17][18]. To investigate these roles more fully, the physical and chemical properties of the drug-acceptor complexes can be enhanced if the complexes are prepared on the nanoscale, and the use of a binary solvent system can help to achieve this goal.…”

Interaction of Human Hemoglobin with Methotrexate

“…In particular, hemoglobin interacts with several drugs: docetaxel [31], alprazolam, a sedative and antidepressant drug [32], and tramadol, a synthetic analgesic [33]. However, there are only a few studies that have focused on the interaction of anticancer drugs with hemoglobin.…”

“…Some studies have shown the interaction of fl avonoids [17-19], dyes [20-22], allosteric effectors [23-25], or other organic compounds [26, 27] with hemoglobin. Moreover, some studies have focused on the interaction of various antibiotics, namely oxytetracycline [28], chloramphenicol [29], and cephalosporins [30], with hemoglobin.In particular, hemoglobin interacts with several drugs: docetaxel [31], alprazolam, a sedative and antidepressant drug [32], and tramadol, a synthetic analgesic [33]. However, there are only a few studies that have focused on the interaction of anticancer drugs with hemoglobin.…”

“…However, there are only a few studies that have focused on the interaction of anticancer drugs with hemoglobin. For example, 5-azacytidine interacts with both human serum albumin and hemoglobin [33]. In this study, the binding affi nity of MTX towards hemoglobin was studied.…”