Spectroscopic study of the interaction of NiII-5-triethyl ammonium methyl salicylidene ortho-phenylendiiminate with native DNA

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

“…The interaction of Ni(II) complexes with DNA has been mainly dependent on the structure of the ligand exhibiting intercalative behavior [19][20][21][22][23] and/or DNA cleavage ability. 24,25 Serum albumin is the major soluble protein constituent in the circulatory system of a wide variety of organisms and it has the ability to reversibly bind to a large variety of endogenous and exogenous ligands such as fatty acids, drugs, and metal ions in the bloodstream. 26,27 The drug-protein complex not only strongly affected the absorption, distribution, metabolism and excretion properties of drugs, but also influenced the drug stability and toxicity during the chemotherapeutic process.…”

Nickel–quinolones interaction. Part 2 – Interaction of nickel(II) with the antibacterial drug oxolinic acid

“…Additionally, nickel complexes of biological interest have been reported with the most structurally characterized acting as antiepileptic [13], anticonvulsant [14] agents or vitamins [15] or showing antibacterial [16][17][18][19], anticancer/ antiproliferative [20][21][22][23][24][25][26], antifungal [16,27,28] and antimicrobial [29] activity. The interaction of Ni(II) complexes with DNA has been mainly dependent on the structure of the ligand exhibiting intercalative behavior [30][31][32] and/or DNA cleavage ability [33,34].…”

Characterization and DNA-interaction studies of 1,1-dicyano-2,2-ethylene dithiolate Ni(II) mixed-ligand complexes with 2-amino-5-methyl thiazole, 2-amino-2-thiazoline and imidazole. Crystal structure of [Ni(i-MNT)(2a-5mt)2]

“…5 Regarding the DNA interaction with Ni(II) complexes showed intercalative behavior and also DNA cleavage ability. 6 In our previous studies a series of mixed-ligand Cu(II) coordination compounds, with bidentate, tridentate and polydentate amines and their Schiff bases, 7,8 trihalides, 9 1,2-dithiolates, 10 and 1,3-thiazoles, thiazolines and imidazole [11][12][13][14] have been utilized as models to investigate their toxicity, 10,12 anti-inflammatory activity, 12 antimicrobial activity against Gram(+) and Gram(À) bacteria 9,11,14 and anti-proliferative activity in vitro 9,11,13,14 and in vivo 10,12 towards various cancer cell lines, for example, HeLa, T47D, HT-29, MCF7, MRC5 and P388 leukemia. A relationship between medicinal effectiveness and physicochemical, structural properties of the ligands and their Cu(II) complexes, have been carried out.…”