Spectroscopic Study on the Interaction of Haloperidol and 2,4-Dinitrophenylhydrazine and its Application for the Quantification in Drug Formulations

Rahman, Nafisur; Sameen, Shahroora; Kashif, Mohammad

doi:10.1080/22297928.2016.1265898

Cited by 28 publications

(9 citation statements)

References 26 publications

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“…As the calculated t -(paired) and F -values at the 95% confidence level were less than the tabulated ones, it was concluded that no significant difference among the two methods was observed. In the interval hypothesis test, the true bias based on recovery experiments was evaluated from the following equation 49,50 where X̅ 1 and X̅ 2 are mean values determined by the proposed and reference methods, respectively. S p and t are the pooled standard deviation and one-sided t -value at the 95% confidence level, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Circular Dichroism Spectroscopy: A Facile Approach for Quantitative Analysis of Captopril and Study of Its Degradation

Rahman

Khan

2019

ACS Omega

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Simple and selective zero- and second-order derivative circular dichroism (CD) spectroscopic methods have been designed for the assay of captopril in commercially available dosage forms. A normal CD spectroscopic scan (zero order) exhibits a negative band at 208 nm (method A) in distilled water. The calibration curve shows a linear response over the concentration range of 10–80 μg mL –1 . The second-order derivative (D2) CD spectrum shows one positive band at 208 nm (method B) and one negative band at 225 nm (method C). Linear calibration curves were obtained in the concentration range of 10–70 μg mL –1 for both the methods (B and C). The detection limits were found to be 1.26, 1.48, and 2.38 μg mL –1 for methods A, B, and C, respectively. The study under stressed acidic, basic, and oxidative conditions showed the degradation of captopril. The proposed methods were validated as per ICH guidelines. All the proposed methods were compared with the reference method to demonstrate its suitability for quality control of captopril in its dosage forms.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Circular Dichroism Spectroscopy: A Facile Approach for Quantitative Analysis of Captopril and Study of Its Degradation

Rahman

Khan

2019

ACS Omega

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“…Furthermore, the quadratic equation shown here was applied to examine the interval hypothesis and to calculate the true bias adopting on the recoveries of experiments [34, 35]:

θ^{2} ((), {\overset{true¯}{x}}_{1}^{2} goodbreak- S_{p}^{2} t^{2} / n_{1}) 2 θ {\overset{true¯}{x}}_{1} {\overset{true¯}{x}}_{2} goodbreak+ ((), {\overset{true¯}{x}}_{2}^{2} goodbreak- S_{p}^{2} t^{2} / n_{2}) goodbreak= 0

…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the quadratic equation shown here was applied to examine the interval hypothesis and to calculate the true bias adopting on the recoveries of experiments [34,35]:…”

Section: Analysis Of Dosage Formmentioning

confidence: 99%

Tuning fluorescence of dapoxetine by blocking of photoinduced electron transfer (PET): Application in real human plasma

et al. 2023

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Photoinduced electron transfer (PET) is the most common mechanism proposed to account for quenching of fluorophores. Herein, the intrinsic fluorescence of dapoxetine (DPX) hydrochloride is in the “OFF” state, owing to the deactivation effect of PET. When the amine moiety is protonated, the fluorescence is restored. Protonation of the nitrogen atom of the tertiary amine moiety in DPX leads to “ON” state of fluorescence due to hindrance of the deactivating effect of PET by protonation of the amine moiety. This permits specific and sensitive determination of DPX in human plasma [lower limit of quantification (LLOQ) = 30.0 ng0.55emmL−1]. The suggested method adopts protonation of DPX using 0.25 M hydrochloric acid in anionic micelles [6.94 mM sodium dodecyl sulfate (SDS)] leads to a marked enhancement of DPX‐fluorescence, after excitation at 290 nm.

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“…The key elements of method performance (accuracy, precision, sensitivity etc.) are well established for laboratory based pharmaceutical analysis [4][5][6]. While advances continued to be made in measurement technology within existing, well established pharmaceutical techniques, the basic requirement of method validation for such techniques remains largely unchanged.…”

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confidence: 99%

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2019

MACIJ

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Spectroscopic Study on the Interaction of Haloperidol and 2,4-Dinitrophenylhydrazine and its Application for the Quantification in Drug Formulations

Cited by 28 publications

References 26 publications

Circular Dichroism Spectroscopy: A Facile Approach for Quantitative Analysis of Captopril and Study of Its Degradation

Circular Dichroism Spectroscopy: A Facile Approach for Quantitative Analysis of Captopril and Study of Its Degradation

Tuning fluorescence of dapoxetine by blocking of photoinduced electron transfer (PET): Application in real human plasma

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