Spectroscopic, thermal and biological studies of coordination compounds of sulfasalazine drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) transition metal complexes

Abstract

The complexations of sulfasalazine (H 3 Suz) with some of transition metals have been investigated. Three types of complexes, [Mn(HSuz) -2 (H 2 O) 4 ]⋅2H 2 O, [M(HSuz) -2 (H 2 O) 2 ]⋅xH 2 O (M = Hg(II), ZrO(II) and VO(II), x = 4, 8 and 6, respectively) and [M(HSuz) -2 (Cl)(H 2 O) 3 ]⋅xH 2 O (M = Cr (III) and Y(III), x = 5 and 6, respectively) were obtained and characterized by physicochemical and spectroscopic methods. The IR spectra of the complexes suggest that the sulfasalazine behaves as a monoanionic bidentate ligand. The thermal decomposition of the complexes as well as thermodynamic parameters (ΔE*, ΔH*, ΔS* and ΔG*) were estimated using Coats-Redfern and Horowitz-Metzger equations. In vitro antimicrobial activities of the H 3 Suz and the complexes were tested.

Outline about Biological and Chemical Coordinations of Some Sulphonyl Drugs

“…The UV-Vis spectra of sulfasalazine and their complexes in DMSO exhibit and detect peaks [22]. There are two absorption maxima peaks at ranges from 215-340 nm and 350-500 nm, assigned to π-π* and n-π* transitions within the organic moiety of sulfasalazine ligand.…”

“…The infrared spectra of sulfasalazine [22] and its com-plexes exhibited with the main coordination bands which reveal the mode of bonding. Concerning the sulfasalazine com-plex, the most important region in the infrared spectra of allcomplexes and the H 3 Suz free ligand (~1700-1300 cm ).…”

“…Sulfasalazine complexes: It seemed of interest to evaluate the effect of heating on the thermal stability of the prepared complexes [22]. The results showed that the complexes lost its hydration water below 573 K. Within the temperature range 573-653 K the coordinated water molecules were liberated.…”

Synthesis, Characterization, Thermal Analysis and Structural Studies of New Complexes with Tetradentate Ligand

“…To a solution of 5,5dimethylcyclohexane-1,3-dione (A) ( 1g,7.142 mmole) in ethanol (10ml), (5) drops of glacial acetic acid were added slowly, then the mixture was added to 4 -amino antipyrine (B) (2.905 g, 14.280 mmole) in ethanol (10 ml). The mixture was refluxed for (4hrs), with stirring at temperature (40 -50 ºc) in water path.…”

Synthesis, chemical structure elucidation, and biological studies on the effect of some vital metal ions on sulfadoxine

“…Subsequent studies revealed more rapid clinical response and faster action when combining sulfadoxine with pyrimethamine against falciparum and vivax malaria, including chloroquine resistant strains, in Southeast Asia and Africa [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]. In the literature survey, the synthesis and characterization of sulfa drugs complexes with some metal ions have been described [39][40][41][42][43][44][45][46][47][48]. In this article, the coordination mode of sulfadoxine chelating via metal ions such as Ca(II), Mg(II), Zn(II), Fe(III), and VO(II) have been investigated.…”