Spectrum of Biological Activity of the Alternaria Fungi Isolated from the Phyllosphere of Herbaceous Plants

Berestetskiy, Alexander; Ганнибал, Ф. Б.; Минкович, Е. В.; Osterman, Ilya А.; Salimova, D. R.; Сергиев, Петр В.; Сокорнова, С. В.

doi:10.1134/s0026261718060036

Cited by 8 publications

(7 citation statements)

References 41 publications

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“…Therefore, endophytes, which are a rich source of bioactive natural compounds, recently attracted renewal interest as producers of insecticidal metabolites [243][244][245]. Phytopathogenic fungi (for example, pathogens of cereals and weeds) can also produce anti-insectan compounds [194,200,246,247]. However, they seem structurally similar to those that produce soil and entomopathogenic fungi with a little practical significance but great potential in ecological studies.…”

Section: Promising Areas Of Researchmentioning

confidence: 99%

“…Approximately 20% of the extracts from cultures of nine Alternaria species showed aphidocidal activity against M. vicea . Among them strains of A. saponariae , A. japonica , A. tenuissima , A. penicillata and A. papavericola were the most prospective producers of insecticidal compounds [ 194 ].…”

Section: Low-molecular-weight Non-volatile Compoundsmentioning

confidence: 99%

“…Phytopathogenic fungi (for example, pathogens of cereals and weeds) can also produce anti-insectan compounds [ 194 , 200 , 246 , 247 ]. However, they seem structurally similar to those that produce soil and entomopathogenic fungi with a little practical significance but great potential in ecological studies.…”

Section: Promising Areas Of Researchmentioning

confidence: 99%

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The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

Berestetskiy

2021

Microorganisms

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Biorational insecticides (for instance, avermectins, spinosins, azadirachtin, and afidopyropen) of natural origin are increasingly being used in agriculture. The review considers the chemical ecology approach for the search for new compounds with insecticidal properties (entomotoxic, antifeedant, and hormonal) produced by fungi of various ecological groups (entomopathogens, soil saprotrophs, endophytes, phytopathogens, and mushrooms). The literature survey revealed that insecticidal metabolites of entomopathogenic fungi have not been sufficiently studied, and most of the well-characterized compounds show moderate insecticidal activity. The greatest number of substances with insecticidal properties was found to be produced by soil fungi, mainly from the genera Aspergillus and Penicillium. Metabolites with insecticidal and antifeedant properties were also found in endophytic and phytopathogenic fungi. It was noted that insect pests of stored products are mostly low sensitive to mycotoxins. Mushrooms were found to be promising producers of antifeedant compounds as well as insecticidal proteins. The expansion of the number of substances with insecticidal properties detected in prospective fungal species is possible by mining fungal genomes for secondary metabolite gene clusters and secreted proteins with their subsequent activation by various methods. The efficacy of these studies can be increased with high-throughput techniques of extraction of fungal metabolites and their analysis by various methods of chromatography and mass spectrometry.

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Section: Promising Areas Of Researchmentioning

confidence: 99%

Section: Low-molecular-weight Non-volatile Compoundsmentioning

confidence: 99%

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The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

Berestetskiy

2021

Microorganisms

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“…TeA, a derivative of tetramic acid, has gained great interest as a model molecule (toxin, pro-drug, and pro-pesticide) since (1) it is produced by a number of phytopathogenic fungi (Alternaria spp., Magnaporthe oryzae, and Phoma sorghina) [71]; (2) this toxin is one of the most common pollutants of food products, while its toxicity to invertebrates and vertebrates has been poorly understood [72,73]; (3) there are acaricides and insecticides (acetyl-CoA carboxylase inhibitors) from the tetramic acid group (for example, and spiropidion) that are effective against sucking arthropods [74]; (4) TeA, along with some other tetramic acid derivatives, is a promising natural herbicide [75], whereas its toxicity to beneficial insects (for example, pollinators, entomophages, and feed protein producers) has not been studied; and (5) methods of chemical synthesis of TeA and its derivatives with various useful properties have been developed [11,71,76,77]. However, the useful properties of direct use of TeA as a pesticide is still under question because of the restricted knowledge on its toxicity.…”

Section: Practical Implicationsmentioning

confidence: 99%

“…For instance, extracts of approximately 20% of tested isolates of nine Alternaria species showed aphicidal activity against the vetch aphid (Megoura viciae). The aphid was most sensitive to organic extracts from cultures of A. saponariae, A. japonica, A. penicillata, A. papavericola, and A. tenuissima [2]. An ethanolic extract from the mycelium of A. papavericola (Brachycladium papaveris) caused mortality of The fungal culture was also grown on a solid substrate: 100 g of pearl barley (PB), 60 mL of water in 500 mL Erlenmeyer flasks.…”

Section: Introductionmentioning

confidence: 99%

Entomotoxic Activity of the Extracts from the Fungus, Alternaria tenuissima and Its Major Metabolite, Tenuazonic Acid

Salimova

Dalinova

Dubovik

et al. 2021

JoF

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The study of fungal antibiotics in their competitive interactions with arthropods may lead to the development of novel biorational insecticides. Extracts of Alternaria tenuissima MFP253011 obtained using various methods showed a wide range of biological activities, including entomotoxic properties. Analysis of their composition and bioactivity allowed us to reveal several known mycotoxins and unidentified compounds that may be involved in the entomotoxic activity of the extracts. Among them, tenuazonic acid (TeA), which was the major component of the A. tenuissima extracts, was found the most likely to have larvicidal activity against Galleria mellonella. In the intrahaemocoel injection bioassay, TeA was toxic to G. mellonella and of Zophobas morio with an LT50 of 6 and 2 days, respectively, at the level of 50 µg/larva. Administered orally, TeA inhibited the growth of G. mellonella larvae and caused mortality of Acheta domesticus adults (LT50 7 days) at a concentration of 250 µg/g of feed. TeA showed weak contact intestinal activity against the two phytophages, Tetranychus urticae and Schizaphis graminum, causing 15% and 27% mortality at a concentration of 1 mg/mL, respectively. TeA was cytotoxic to the Sf9 cell line (IC50 25 µg/mL). Thus, model insects such as G. mellonella could be used for further toxicological characterization of TeA.

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Ecological Role of Phytotoxic Secondary Metabolites Produced by Phytopathogenic Fungi

Berestetskiy,

2024

Reference Series in Phytochemistry

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Spectrum of Biological Activity of the Alternaria Fungi Isolated from the Phyllosphere of Herbaceous Plants

Cited by 8 publications

References 41 publications

The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management

Entomotoxic Activity of the Extracts from the Fungus, Alternaria tenuissima and Its Major Metabolite, Tenuazonic Acid

Ecological Role of Phytotoxic Secondary Metabolites Produced by Phytopathogenic Fungi

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