Spectrum of biopsy proven renal disease in <scp>S</scp>outh <scp>A</scp>sian children: <scp>T</scp>wo decades at a tropical tertiary care centre

Mohapatra, Anjali; Kakde, Shailesh; Annapandian, VM; Valson, Anna T; Duhli, Neelaveni; Korula, Anila; Matthai, Smita Mary; Pulimood, Anna; David, Vinoi George; Schmeißer, Alexander; Jacob, Shibu; Varughese, Santosh; Basu, Gopal; Tamilarasi, V; John, George T.

doi:10.1111/nep.13160

Cited by 13 publications

(15 citation statements)

References 34 publications

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“…The mean age at biopsy was about 10 years, which is corresponding to results reported in other countries [7-9, 11, 18, 22, 31]. However, sometimes that mean age was higher [15,16] or lower [13,[28][29][30]32].…”

Section: Discussionsupporting

confidence: 70%

“…In our study, acute renal failure was a less important reason for renal biopsy, while some studies reported similar [7,9,11,37], higher (10.7-17.5%) [2,10,18,20], or lower numbers (1.4-4.4%) [8,15]. Similarly, chronic renal failure, was also less important reason for renal biopsy in our research.…”

Section: Indications For Renal Biopsycontrasting

confidence: 39%

“…Among 23 studies which have been analysed and compared to our study, only 9 used a similar technique and performed three different diagnostic techniques together: LM, IM and EM [1,7,9,12,17,19,22,29,33]. Eight studies did not used EM at all [11,13,16,18,20,28,30,34], 5 used EM partly [2,4,6,14,15], while one used both IM and EM only partly [8]. The described technical heterogeneity could sometimes result in significant differences in PHD-s.…”

Section: Discussionmentioning

confidence: 99%

“…Crescentic GN was found only in one patient as well as EDGN. In contrast, a Spanish study by Lopez-Gomez et al listed thrombotic microangiopathy as the main reason for renal biopsy, while in South Asian children HUS and TIN were also an important cause for AKI [15,37]. A report from the Italian National Registry of Renal Biopsies in Children indicated that crescentic GN was the most common disease in the group of acute renal failure, followed by TIN [2].…”

Section: Phd-s In the Group Of Patients With Isolated Haematuriamentioning

confidence: 92%

“…National registries of renal biopsies showed a variety of renal diseases and different epidemiology worldwide [1][2][3][4][5][6]. Renal biopsies are still very important for renal diseases management in children [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia

et al. 2020

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Background: Information about renal diseases in children is available from national registries of renal biopsies. Aim of the study was to compare the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from pediatric population in the Croatian region of Dalmatia. Methods: Out of 231 pediatric patients with suspected glomerular and tubulointerstitial diseases, 54 underwent ultrasound-guided renal biopsy at University Hospital of Split. Kidney allograft biopsy, and re-biopsy were excluded. The biopsy sections were examined under light microscopy, immunofluorescence and electron microscopy. The data was reviewed to determine the pathohistological spectrum and clinicopathologic correlations. We retrospectively analyzed kidney biopsy data from 2008 to 2017 and compared them to that between 1995 and 2005.Results: The mean age of patients was 9.84 ± 5.4 years. Male:female ratio was 1.2:1. The main indications for biopsy were pure nephrotic syndrome without hematuria (25.9%), non-nephrotic proteinuria with haematuria (22.2%), nephritic syndrome with nephrotic proteinuria (18.5%), and isolated hematuria (16.7%). The most common pathohistological findings were IgA nephropathy (IgAN, 24.1%), minimal change disease (MCD, 16.7%), Henoch-Schönlein purpura glomerulonephritis (HSPN, 14.8%), Alport syndrome and focal segmental glomerulosclerosis (AS and FSGS, 11.1% each), tubulointerstitial nephritis and membranous glomerulopathy (TIN and MGN, 3.7% each), while other cases were diagnosed rarely. Conclusions:Changes in epidemiology of renal diseases in children between the analyzed periods showed an increasing trend of IgAN, MCD, HSPN, AS and FSGS, while mesangioproliferative glomerulonephritis (MesPGN) and endoproliferative glomerulonephritis (EDGN) showed a decreasing trend that can be explained with the new pathohistological classification.

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Section: Discussionsupporting

confidence: 70%

Section: Indications For Renal Biopsycontrasting

confidence: 39%

Section: Discussionmentioning

confidence: 99%

Section: Phd-s In the Group Of Patients With Isolated Haematuriamentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia

et al. 2020

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Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)

et al. 2021

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Renal pathology in adult and paediatric population of Japan: review of the Japan renal biopsy registry database from 2007 to 2017

Goto,

Imaizumi,

Hamada

et al. 2023

J Nephrol

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Background The Japan Renal Biopsy Registry (J-RBR), a nationwide, web-based, registry system, started in 2007. This study aimed to summarise the epidemiology of biopsy-diagnosed kidney disease in Japan over 10 years. Methods We analysed the J-RBR database, from 2007 to 2017. Patients’ clinical data collected at the time of biopsy and histopathological diagnoses were used for epidemiological and clinicopathologic analyses. Results The predominant renal biopsy diagnoses were immunoglobulin A nephropathy (39.2%), lupus nephritis (6.5%) and minimal change disease (6.0%) in younger adults (19–64 years), and membranous nephropathy (17.4%), antineutrophil cytoplasmic antibody-associated vasculitis or anti-glomerular basement membrane glomerulonephritis (13.0%), and immunoglobulin A nephropathy (12.5%) in older adults (≥ 65 years). The percentages of patients diagnosed with membranoproliferative glomerulonephritis and immunoglobulin A nephropathy decreased, whereas those with immunoglobulin A vasculitis and diabetic nephropathy increased over the decade. In paediatric patients (< 19 years), immunoglobulin A nephropathy (36.1%), minimal change disease (17.6%), and immunoglobulin A vasculitis (8.6%) were the predominant diagnoses. The percentage of patients diagnosed with immunoglobulin A vasculitis increased over the decade. Based on the sex distribution, minimal change disease and membranous nephropathy were predominant in men aged < 20 and > 40 years, respectively, whereas immunoglobulin A vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis or anti-glomerular basement membrane glomerulonephritis were predominant in women in their 20s and 30s and aged < 50 years, respectively. Immunoglobulin A nephropathy was predominant in men at most ages and in women in their 20s to 40s. Conclusions This study describes the distribution and changes in kidney biopsy diagnoses over 10 years in Japan and paves the way for future research on kidney diseases in adults and children. Graphical abstract

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Spectrum of biopsy proven renal disease in South Asian children: Two decades at a tropical tertiary care centre

Abstract: This study provides the largest data on biopsy proven renal disease in children from South Asia published till date and highlights important differences in the spectrum and trends of kidney disease compared to data from other regions.

Cited by 13 publications

References 34 publications

Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia

Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia

Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)

Renal pathology in adult and paediatric population of Japan: review of the Japan renal biopsy registry database from 2007 to 2017

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