In this paper, we show that the eigenvalues of certain classes of Cayley graphs are integers. The (n, k, r)-arrangement graph A(n, k, r) is a graph with all the k-permutations of an n-element set as vertices where two k-permutations are adjacent if they differ in exactly r positions. We establish a relation between the eigenvalues of the arrangement graphs and the eigenvalues of certain Cayley graphs. As a result, the conjecture on integrality of eigenvalues of A(n, k, 1) follows.