Spectrum of CD30+ Lymphoid Proliferations in the Eyelid

Abstract

Purpose To report the clinicopathologic features of three patients with CD30+ lymphoid proliferations of the eyelid. Design Retrospective case series. Participants Patients with cutaneous CD30+ lymphoproliferative lesions of the eyelid. Methods Three patients with CD30+ non-mycosis fungoides T cell lymphoid infiltrates of the eyelid were identified. The histories, clinical findings, pathologic features including immunohistochemical staining, treatments and outcomes were reviewed and compared. Main Outcome Measures Pathologic findings including immunohistochemical analysis. Results The patients included an 81-year-old man, an 18-year-old man, and a 42-year-old woman, with CD30+ lymphoid proliferations of the eyelid and adjacent soft tissue. The first patient had an isolated crateriform eyelid lesion that was classified as lymphomatoid papulosis (LyP). The second patient had an isolated multinodular lesion of the eyelid that was classified as cutaneous anaplastic large cell lymphoma (cALCL). The third patient presented with eyelid edema with an underlying mass and was found to have widely disseminated anaplastic large cell lymphoma (ALCL). Diagnoses were dependent on clinical findings. Conclusions CD30+ lymphoid proliferations represent a spectrum of conditions ranging from indolent LyP, to moderately aggressive cALCL, and to highly aggressive ALCL. Interpretation of the pathologic findings in CD30+ lymphoid proliferations is based in part on clinical findings.

A Case of Tofacitinib-Induced Lymphomatoid Papulosis With Ocular Involvement

“…7 Cutaneous periorbital and oral mucosal involvement is rare but has been reported; ocular mucosal involvement specifically has not been reported. 8,9 Some data implicate activation of the JAK-STAT pathway with the development of LyP. A recent study of 12 patients with CD30 + lymphoproliferative disorders, including 6 LyP patients, suggested that an increased frequency of activating mutations in the JAK-STAT pathway may contribute to the pathogenesis of these diseases.…”

“…7 Cutaneous periorbital and oral mucosal involvement is rare but has been reported; ocular mucosal involvement specifically has not been reported. 8,9…”

Cutaneous Anaplastic Large Cell Lymphoma: A Case Report about Masking Effect of Facial Masks in the COVID-19 Pandemic

“…PC-ALCL typically presents on head, neck, and extremities in immunocompromised patients as a rapidly growing solitary or localized group of nodules that may ulcerate. 8…”

“…PC-ALCL typically presents on head, neck, and extremities in immunocompromised patients as a rapidly growing solitary or localized group of nodules that may ulcerate. 8 The possibility of systemic ALCL must be considered in the evaluation of PC-ALCL. Our patient was assessed for systemic disease with PET/CT and underwent serial full-body skin exams for other cutaneous findings, both preoperatively for treatment planning, and postoperatively for surveillance of recurrent lymphoma.…”

ALK-Negative Anaplastic Large Cell Lymphoma: Current Concepts and Molecular Pathogenesis of a Heterogeneous Group of Large T-Cell Lymphomas

“…ALK- ALCL involves the lymph nodes in ~50% of cases whereas extranodal involvement is less frequent [ 14 , 15 ]. Relatively common extranodal sites of involvement include the skin (excluding pc-ALCL), soft tissue, the liver and the lungs, whereas rare sites of involvement include the oropharynx, the gastrointestinal tract, the orbit, the brain, and the testes [ 3 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Skin lesions may be solitary or multiple in the form of papules, nodules, or tumors.…”