Spectrum of central nervous system involvement in rheumatic diseases: pictorial essay

Vieira, Renata Mendes; Nascimento, Felipe Barjud Pereira do; Júnior, Alcino Alves Barbosa; Pereira, Inês Minniti Rodrigues; Sachetto, Zoraida; Appenzeller, Simone; Reis, Fabiano

doi:10.1590/0100-3984.2016.0066

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…Despite being an uncommon symptom, neurological involvement (neuro-Behçet’s disease) is one of the most severe causes of long-term morbidity and can lead to cerebral venous thrombosis. 11 , 12 …”

Section: Discussionmentioning

confidence: 99%

“…Despite being an uncommon symptom, neurological involvement (neuro-Behçet's disease) is one of the most severe causes of long-term morbidity and can lead to cerebral venous thrombosis. 11,12 The majority of cases of CVTs are due to thrombosis of the superior sagittal sinus, transverse sinuses, cortical veins, or a combination of sinuses. In the literature, there have been very few cases of isolated inferior sagittal sinus thrombosis.…”

Section: Discussionmentioning

confidence: 99%

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Isolated Inferior Sagittal Sinus Thrombosis in Young Patient: Rare Case Report

Sheikh Hassan,

Ahmed Ibrahim,

Nakus

et al. 2023

IMCRJ

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Cerebral venous thrombosis (CVT) is a less common type of stroke, mostly in young patients. The majority of these cases are due to thrombosis of superior sagittal sinus and transverse sinus. Isolated thrombosis of the inferior sagittal sinus is very rare. Here, we report a 22-year-old male patient with no significant past medical history who presented to the emergency department of our hospital with a convulsion, decreased level of consciousness, and right side weakness. His laboratory investigations, including the coagulation profile, were normal. A non-contrast brain CT showed a 5 × 3 cm hematoma in the left parasagittal parietal lobe with no associated midline shift or intraventricular extension. The cerebral magnetic resonance (MR) angiogram did not show any underlying aneurysm or vascular lesion. However, the cranial MR venogram showed inferior sagittal sinus thrombosis, while other cranial veins and dural sinuses were patent. The patient was admitted to the hospital and managed with low-molecular-weight heparin and warfarin sequentially. He had significant improvement (consciousness and weakness have improved, and seizures are under control). This present case illustrates a rare case of isolated cerebral venous thrombosis and also reviews the known literature on this condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Isolated Inferior Sagittal Sinus Thrombosis in Young Patient: Rare Case Report

Sheikh Hassan,

Ahmed Ibrahim,

Nakus

et al. 2023

IMCRJ

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“…Behçet’s disease is a chronic, multisystem, relapsing infammatory perivasculitis. Although neurological involvement (neuro-Behçet’s disease) is a rare manifestation, it is one of the most serious causes of long-term morbidity and can result in cerebral venous thrombosis( 10 , 11 ), as depicted in Figure 10 .…”

Section: Predisposing Factors For Cvtmentioning

confidence: 99%

“…Behçet's disease) is a rare manifestation, it is one of the most serious causes of long-term morbidity and can result in cerebral venous thrombosis (10,11) , as depicted in Figure 10.…”

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confidence: 99%

Cerebral venous thrombosis: imaging patterns

et al. 2022

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Cerebral venous thrombosis (CVT) is an uncommon condition that is potentially reversible if properly diagnosed and promptly treated. Although CVT can occur at any age, it most commonly affects neonates and young adults. Clinical diagnosis is difficult because the clinical manifestations of CVT are nonspecific, including headache, seizures, decreased level of consciousness, and focal neurologic deficits. Therefore, imaging is crucial for the diagnosis. Radiologists should be able to identify the findings of CVT and to recognize potential imaging pitfalls that may lead to misdiagnosis. Thus, the appropriate treatment (anticoagulation therapy) can be started early, thereby avoiding complications and unfavorable outcomes.

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“…The autonomic nervous system (ANS) is vital in regulating cardiac functions. Several rheumatologic diseases, including AS, are characterized by the involvement of the central nervous system (CNS), peripheral nervous system (PNS), as well as autonomic nervous system (ANS) [19][20][21][22]. The involvement of the ANS has been evaluated earlier in AS by HRV and cardiovascular reflex tests.…”

Section: Introductionmentioning

confidence: 99%

Heart Rate Variability in Patients of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis

Sharma,

Dholariya,

Parchwani

et al. 2024

Cureus

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Patients with ankylosing spondylitis (AS) have a significantly higher risk of cardiovascular morbidities. The participation of the autonomic nervous system (ANS) in AS is still unknown and inconclusive. Heart rate variability (HRV) is defined as the variability of the time interval between two consecutive heartbeats. This meta-analysis aims to detect the association of HRV and its various parameters with AS patients by comparing them to healthy controls. Research literature was searched in PubMed, Embase, and Cochrane Library databases from inception to April 2022. The Review Manager 5 (RevMan) Version 5.4 software was used to analyze the data. In addition, the protocol of systematic review is registered in the PROSPERO database with ID CRD42022336484. This study includes a total of nine case-control studies with a total of 923 patients; 409 with AS and 514 healthy controls. The root mean square of successive differences between normal heartbeats (RMSSD) [standardized mean difference (SMD); -0.47, 95% CI: -0.69 to -0.25, p < 0.0001], proportion of NN50 (pNN50) (SMD; -0.89, 95% CI: -1.74 to -0.04, p = 0.04) and HRV (SMD; -1.11, 95% CI: -1.53 to 0.69, P < 0.00001) were significantly low in AS cases compared to healthy controls. The HRV value was also significantly low in patients with high Bath ankylosing spondylitis disease activity (BASDAI) index (SMD: -1.45, 95% CI: -2.45 to -0.36, p < 0.009). HRV (parasympathetic activity) was significantly lowered in AS patients compared to healthy controls.

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Spectrum of central nervous system involvement in rheumatic diseases: pictorial essay

Cited by 9 publications

References 15 publications

Isolated Inferior Sagittal Sinus Thrombosis in Young Patient: Rare Case Report

Isolated Inferior Sagittal Sinus Thrombosis in Young Patient: Rare Case Report

Cerebral venous thrombosis: imaging patterns

Heart Rate Variability in Patients of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis

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