Spectrum of Clinicopathologic Manifestations of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: A Multicenter Study

Corrado, Domenico; Basso, Cristina; Thiene, Gaetano; McKenna, William J.; Davies, Michael J.; Fontaliran, F; Nava, Andrea; Silvestri, Furio; Blomström‐Lundqvist, Carina; Włodarska, Elżbieta K.; Fontaine, G.; Camerini, F

doi:10.1016/s0735-1097(97)00332-x

Cited by 884 publications

(668 citation statements)

References 35 publications

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“…ARVC is a progressive disease that might lead to left ventricular failure and ultimately to biventricular pump failure [18]. Thromboembolic events are one of the complications in end stage ARVC because of progressive dilatation [43].…”

Section: Heart Failure Management In Arvcmentioning

confidence: 99%

“…ARVC is no longer considered an isolated RV disease [18]. LV changes either macroscopic or microscopic have been found in more than 75% of 42 examined hearts in patients with ARVC [18].…”

Section: Cardiac Transplantationmentioning

confidence: 99%

“…ARVC is no longer considered an isolated RV disease [18]. LV changes either macroscopic or microscopic have been found in more than 75% of 42 examined hearts in patients with ARVC [18]. These findings were more age dependent and more common in patients with longstanding clinical history of ARVC [18].…”

Section: Cardiac Transplantationmentioning

confidence: 99%

“…LV changes either macroscopic or microscopic have been found in more than 75% of 42 examined hearts in patients with ARVC [18]. These findings were more age dependent and more common in patients with longstanding clinical history of ARVC [18]. Hence, ARVC can follow multiple pathological and clinical phases [14].…”

Section: Cardiac Transplantationmentioning

confidence: 99%

“…This leads to regional wall motion abnormalities which progress to global regional wall motion abnormalities and right ventricular dilation which in turn causes VA, right ventricular failure, and SCD [14,18]. In recent years, several genetic mutations that lead to cardiac cell defects have been discovered and linked to ARVC such as desmoplakin, plakoglobin, and plakophilin [19].…”

Section: Introductionmentioning

confidence: 99%

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Right ventricular dysplasia: management and treatment in light of current evidence

Idris

Shah

Park

2018

Journal of Community Hospital Internal Medicine Perspectives

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Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare cardiovascular disease that predisposes to ventricular arrhythmias potentially leading to sudden cardiac death (SCD). ARVC varies considerably with multiple clinical presentations, ranging from no symptoms to cardiac arrhythmias to SCD. ARVC prevalence is not well known, but the estimated prevalence in the general population is 1:5000. Diagnosis of ARVC can be made by using the Revised European Society of Cardiology criteria for ARVC that includes ventricular structural and functional changes, ECG abnormalities, arrhythmias, family and genetic factors. The management of ARVC is focused on prevention of lethal events such as SCD. Implantable cardioverter defibrillator placement is the only proven mortality benefit in treatment of ARVC. Other treatment strategies include medications such as beta blockers and antiarrhythmics, radiofrequency ablation, surgery, cardiac transplantation, and lifestyle changes. All these interventions help in symptomatic treatment but none of them have proved to decrease mortality rates. ARVC is a progressive disease that leads to SCD if not treated appropriately. Management of these diseases has been a challenge for physicians. With the advent of technology and many new drugs/devices under clinical investigation, this might change in the future. However, while advances in technologies have helped elucidate many aspects of these diseases, many mysteries still remain of this unique disease. With continued research, we can expect more cost-effective and patient-friendly drug therapies and ablation techniques to be developed in the near future.

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Section: Heart Failure Management In Arvcmentioning

confidence: 99%

“…ARVC is no longer considered an isolated RV disease [18]. LV changes either macroscopic or microscopic have been found in more than 75% of 42 examined hearts in patients with ARVC [18].…”

Section: Cardiac Transplantationmentioning

confidence: 99%

Section: Cardiac Transplantationmentioning

confidence: 99%

Section: Cardiac Transplantationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Right ventricular dysplasia: management and treatment in light of current evidence

Idris

Shah

Park

2018

Journal of Community Hospital Internal Medicine Perspectives

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Trends in Sudden Cardiovascular Death in Young Competitive Athletes After Implementation of a Preparticipation Screening Program

Corrado

Basso²,

Pavei³

et al. 2006

JAMA

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1,335

1,064

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The incidence of sudden cardiovascular death in young competitive athletes has substantially declined in the Veneto region of Italy since the introduction of a nationwide systematic screening. Mortality reduction was predominantly due to a lower incidence of sudden death from cardiomyopathies that paralleled the increasing identification of athletes with cardiomyopathies at preparticipation screening.

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One Beat Is All It Takes—Wide Complex Tachycardia in a Middle-aged Man

2023

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Spectrum of Clinicopathologic Manifestations of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: A Multicenter Study

Abstract: LV involvement was found in 76% of hearts with ARVC, was age dependent and was associated with clinical arrhythmic events, more severe cardiomegaly, inflammatory infiltrates and heart failure. ARVC can no longer be regarded as an isolated disease of the right ventricle.

Cited by 884 publications

References 35 publications

Right ventricular dysplasia: management and treatment in light of current evidence

Right ventricular dysplasia: management and treatment in light of current evidence

Trends in Sudden Cardiovascular Death in Young Competitive Athletes After Implementation of a Preparticipation Screening Program

One Beat Is All It Takes—Wide Complex Tachycardia in a Middle-aged Man

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