Spectrum of Common Pediatric Neurological Disorders: A Cross-Sectional Study From Three Tertiary Care Centres Across Pakistan

Chand, Prem; Sultan, Tipu; Kulsoom, Shazia; Jan, Farida; Ibrahim, Shahnaz; Mukhtiar, Kairunnisa; Awan, Safia; Rafique, Ibrar; Khan, Durray Shahwar A.; Sulaiman, Asna; Saqib, Muhammad; Sajid, Muhammad; Padhani, Zahra Ali; Das, Jai K; Soomro, Shazia; Wasay, Mohammad

doi:10.1016/j.pediatrneurol.2022.09.005

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…In our study the mean was 62.04 months with a standard deviation of 49.57 months. This result is somewhat similar to that obtained by Akodu, et al in Nigeria, in whom the 1 to 60 month age group was the most represented (37.6%), with an average age of 52.96 ± 52.62 months, but different from that of Chand, et al in Pakistan, who recorded a predominance of children over 5 years of age (52%), with an average age of 6.04 ± 4.71 years [17,18]. In our context, the predominance of children under 5 years of age (1 to 59 months) is due to the fact that at this age the child is still growing, has vulnerable cerebral structures, is immunologically immature and is more exposed to a variety of common infections.…”

Section: Outcomesupporting

confidence: 88%

Epidemiological, Clinical and Therapeutic Aspects of Neuropaediatric Emergencies in Children Aged 1 Month to 15 Years in the Paediatric Emergency Department of CHU-Gabriel Toure

2024

J Cli Ped Chi Res

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Introduction: Paediatric neurological emergencies are a major public health problem worldwide, in Africa and in Mali. Despite the scale and complexity of paediatric neurological emergencies, there is little data in the literature in Africa and particularly in Mali on these neurological disorders in paediatrics. Aim: The aim of our study was to examine the epidemiological, clinical and therapeutic aspects of neuropaediatric emergencies in children aged between 1 month and 15 years in the paediatric department of the CHU-Gabriel Touré in 2021. Patients and Methods: This was a cross-sectional study conducted over a twelve-month period (01 January to 31 January 2021) in children aged 1 month to 15 years hospitalised in the paediatric emergency department for a neurological emergency. Results: The frequency of hospitalization was 18.35%. The age group 12 to 60 months accounted for 43.7%. The sex ratio was 1.44. Convulsion was the most frequent reason for hospitalisation (49.3%). Delayed psychomotor development was noted in 4%. Around 3% of the children had not been vaccinated. On clinical neurological examination, the signs observed were : Altered consciousness (88.3%), convulsion (61%), and axial hypotonia (29%). Focal convulsions accounted for 59%, and 45.7% were febrile. The main diagnoses were neuromalaria, hyperpyretic convulsion and meningitis (68.3%, 7% and 6.3% respectively). The death rate within the first 24 hours was 48%. The average length of hospitalisation was 5.03 +/-4.5 days, with extremes of 1 and 21 days. Conclusion: Neuropaediatric emergencies are a major paediatric health problem. They are frequent and contribute substantially to infant and child mortality in our context.

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Section: Outcomesupporting

confidence: 88%

Epidemiological, Clinical and Therapeutic Aspects of Neuropaediatric Emergencies in Children Aged 1 Month to 15 Years in the Paediatric Emergency Department of CHU-Gabriel Toure

2024

J Cli Ped Chi Res

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“…Diseases such as polio, rabies and tetanus are still widespread and have a high mortality. 1,2 For these reasons, the 75 th World Health Assembly adopted the Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders 2022-2031 (IGAP), which prioritizes brain disorders in health policymaking. Through IGAP, neurology will be given a greater importance at the national level and low and low-and middle-income countries (LMICs) will especially benefit since they are disproportionally affected by neurological disorders.…”

mentioning

confidence: 99%

“…The common causes were febrile fits (50.3%), encephalitis/meningitis (33.8%) and epilepsy/status epilepticus (9.1%). 2 Stroke has an alarming yearly incidence of 250/100,000 population in Pakistan, with the highest cause of death in Pakistan reporting for 67.3% among other neurological diseases; Alzheimer's disease and other dementias follow. 7 In a study that took place in an urban slum in Karachi, Pakistan, stroke had an incidence of 21.8% (66.4% females).…”

mentioning

confidence: 99%

World health organization intersectoral global action plan (WHO-IGAP); implications and impact on neurological care in Pakistan

Wasay¹,

Younis²,

Malik³

et al. 2023

PJNS

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Mesenchymal Stem Cell-Induced Neuroprotection in Pediatric Neurological Diseases: Recent Update of Underlying Mechanisms and Clinical Utility

Chen,

Ren,

Zhou

et al. 2024

Appl Biochem Biotechnol

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Spectrum of Common Pediatric Neurological Disorders: A Cross-Sectional Study From Three Tertiary Care Centres Across Pakistan

Cited by 4 publications

References 13 publications

Epidemiological, Clinical and Therapeutic Aspects of Neuropaediatric Emergencies in Children Aged 1 Month to 15 Years in the Paediatric Emergency Department of CHU-Gabriel Toure

Epidemiological, Clinical and Therapeutic Aspects of Neuropaediatric Emergencies in Children Aged 1 Month to 15 Years in the Paediatric Emergency Department of CHU-Gabriel Toure

World health organization intersectoral global action plan (WHO-IGAP); implications and impact on neurological care in Pakistan

Mesenchymal Stem Cell-Induced Neuroprotection in Pediatric Neurological Diseases: Recent Update of Underlying Mechanisms and Clinical Utility

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