Spectrum of Disease in Hospitalized Newborns with Congenital Micrognathia: A Cohort of 3,236 Infants at North American Tertiary-Care Intensive Care Units

The Children’s Hospitals Neonatal Consortium (CHNC), established in 2010, seeks to improve care for infants with medically and surgically complex conditions who are cared for in level IV regional children’s hospital NICUs across North America. Through patient-level individual data collection, comparative benchmarking, and multicenter quality improvement work, CHNC has contributed to knowledge and improved outcomes, leveraging novel collaborations between and across institutions. Focusing on antenatal and inpatient care for infants with surgical conditions including congenital diaphragmatic hernia, gastroschisis, and necrotizing enterocolitis, we summarize the progress made in these infants′ care. We highlight the ways in which CHNC has enabled multidisciplinary and multicenter collaborations through the facilitation of diagnosis-specific focus groups, which enable comparative observations of outcomes through quality improvement and research initiatives. Finally, we review the importance of postbirth hospitalization needs of these infants and the application of telemedicine in this population.

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Inter-Center Variations in Inpatient Outcomes for Infants with Gastroschisis from the Children's Hospitals Neonatal Consortium

Ling,

Zaniletti,

Riddle

et al. 2024

Preprint

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Objective: To estimate inter-center variation (ICV) in hospital length of stay (LOS) and oral feeding at discharge among infants with gastroschisis. Study Design: Children's Hospitals Neonatal Consortium's (CHNC) database was used to identify hospitalized survivors with gastroschisis. Two outcomes were evaluated: LOS and discharge without tube feedings. Hospital outcomes were evaluated in unadjusted and adjusted analyses. Generalized linear models with log link for gamma distribution was used to model LOS and logistic regression for discharge without tube feeds. Results: For 3987 surviving infants with gastroschisis, LOS and discharge within 70 days with exclusively oral feeding, both exhibited significant ICV. Differences persisted in multivariable analyses. Risk adjusted LOS (68% difference) and oral feeding at discharge (6.4-fold difference) varied significantly between centers. Conclusion: Hospital of care was independently associated with LOS and exclusive oral feeding at discharge rates for infants with gastroschisis. Management differences, potentially influenced by parental preferences, contributed to variation.

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Spectrum of Disease in Hospitalized Newborns with Congenital Micrognathia: A Cohort of 3,236 Infants at North American Tertiary-Care Intensive Care Units

Cited by 3 publications

References 24 publications

Inter-center variations in inpatient outcomes for infants with gastroschisis from the Children’s Hospitals Neonatal Consortium

Inter-center variations in inpatient outcomes for infants with gastroschisis from the Children’s Hospitals Neonatal Consortium

Cutting into the NICU: Improvements in Outcomes for Neonates with Surgical Conditions

Inter-Center Variations in Inpatient Outcomes for Infants with Gastroschisis from the Children's Hospitals Neonatal Consortium

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