Spectrum of Early Onset and Late Onset Ventilator Associated Pneumonia (VAP) in a Tertiary Care Hospital of Bangladesh: A Prospective Cohort Study

Mallick, Uzzwal Kumar; Faruq, Mohammad Omar; Ahsan, Asm Areef; Fatema, Kaniz; Ahmed, Fatema; Asaduzzaman, Mohammad; Islam, Motiul; Sultana, Amina

doi:10.3329/bccj.v3i1.24095

Cited by 10 publications

(10 citation statements)

References 20 publications

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“…This study showed that patients in the age group of 50-70 years were more prone to develop VAP and this result was similar to Mallick et al 17 and Chi et al 18 . The incidence of VAP was more in males (67.5%) compared to females (32.5%) which was similar to studies conducted by Mallick et al 17 , Chi et al 18 , Sharma et al 19 and Aly et al 20 .…”

Section: Discussionsupporting

confidence: 89%

Microbial Profile of Pneumonia in Patients with Late Onset Ventilator Associated Pneumonia

Fathy

Said²,

Hager³

2019

Egyptian Journal of Medical Microbiology

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Ventilator-associated pneumonia (VAP) is pneumonia occurring 48-72 hours or later following endotracheal intubation. It is characterized by the presence of an infiltrate, whether new or progressive, signs of systemic infection (fever, leukocytosis), change in sputum, and detection of an agent. VAP is mainly acquired through either major or micro aspiration of oropharyngeal organisms into the distal bronchi, directly or via reflux from the stomach into the oropharynx. Objectives: This study aimed to measure VAP rates, identify the causative organisms and demonstrate whether an association exists between bacterial pathogens causing late onset VAP and bacteria isolated from gastric aspirate in mechanically ventilated patients admitted to the Respiratory Intensive

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Section: Discussionsupporting

confidence: 89%

Microbial Profile of Pneumonia in Patients with Late Onset Ventilator Associated Pneumonia

Fathy

Said²,

Hager³

2019

Egyptian Journal of Medical Microbiology

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“…Mechanical ventilation increases the risk for ventilator-associated pneumonia (VAP) since it bypasses the usual host defense mechanisms of the upper airways (Diaconu et al, 2018). Although it was beyond the scope of the study to determine VAP rates, the most frequent organisms isolated were XDR A. baumannii, K. pneumoniae and P. aeruginosa, which are also commonly isolated among patients with VAP (Golia et al, 2013;Mallick et al, 2015). We found no difference in length of ICU stay between those who had clinical success and failure, although patients who were successfully treated had longer total length of hospital stay.…”

Section: Discussionmentioning

confidence: 99%

The clinical profile and outcomes of adult patients given intravenous colistin for multidrug-resistant gram negative infections in a Philippine tertiary hospital

Abad

2020

International Journal of Infectious Diseases

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“…The culture positivity rate in our study is similar to another study conducted by Ahsan et al, the positive samples were 72.3%. 18 However 83% culture positive isolates were also reported in a study conducted by Mallick et al 19 .…”

Section: Materials and Methodmentioning

confidence: 80%

Bacteriological profile of Tracheal aspirate and their Antimicrobial Sensitivity Pattern in a Tertiary Care Hospital in Dhaka city

T¹,

Ferdous²,

Ullah³

et al. 2022

J Med Sci Res

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Background: The majority of nosocomial infections are seen in intensive care units and they course with higher rates of mortality and morbidity worldwide. Objectives: To identify the current microbial isolates and their antimicrobial susceptibility pattern from the tracheal aspirate culture in a tertiary care hospital in Dhaka city.Materials and Method: This retrospective study was conducted in the department of Microbiology at Holy Family Red Crescent Medical College Hospital, Dhaka from January 2020 to June 2021 for a period of one and a half years. Written consent was taken from the corresponding authority.A total of 109 samples were collected from tracheal aspirates of the patients who were admitted to the hospital with the critically ill patients in intensive care units.Microsoft Excel software was used for data analysis.Results: A total of 109 samples were analyzed. Of them, the predominant populations were male 73(66.97%) and the remaining were female 36(33.03%). Out of 109 samples, 70 (64.22%)was culture positive. Culture negative was 39 (35.78%). The majority of isolates were Gram-negative bacteria. Among them, predominant bacteria wereKlebsiella spp. 43(61.43%) followed by Acinetobacter spp 19(27.15%), Pseudomonas spp. 05(07.14%) & Gram-positive isolates waswereaph. Aureus 03(04.28%). Klebsiella species showed higher sensitivity totigecycline 97.67%, colistin 93.02%, amikacin 65.11% and meropenem 37.20% & gentamicin 30.23%. Other drugs showed wer sensitivity to axicillin/clavulenic acid 18.60%, and ciprofloxacin 18.60% , trimethoprim/ sulfamethoxazole 09.30%, ceftazidime & cefuroxime 04.65% and lowest sensitivity shown in ceftriaxone 02.32%. Acinetobacter speciesshowed higher sensitivityin colistin at 100% and tigecycline at 47.36%. Other drugs like amikacinand trimethoprim/ sulfamethoxazole 15.78% and the lowest sensitivity were shown in meropenem 10.52% and high resistance in gentamycin, ceftriaxone, ceftazidime, and ciprofloxacin.Pseudomonas spp. showed the highest sensitivity 60.00% to piperacillin-tazobactam, amikacin, imipenem, meropenem, and gentamycin, 40.00% to ciprofloxacin, 20.00% to ceftazidime & cefepime.All the isolate of Staph. aureus was the highest sensitive 100% to vancomycin and linezolid, 66.66% sensitive to amikacin, trimethoprim/ sulfamethoxazole, tetracycline, and gentamicin, 33.33% showed lower sensitivityto amoxicillin/ clavulanic acid, cloxacillin and ciprofloxacin.Conclusion:This study aimed to investigate thedistribution of pathogenic microorganisms isolated from tracheal aspirate and their antibiotic sensitivity profile in intensive care units. A periodic review of the bacteriological profile and antibiotic sensitivity pattern is highly essential for the clinician to treat critically ill patients in ICU. Antibiotic policy & infection control programs should be included in every hospital to reduce this drug resistance.

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Spectrum of Early Onset and Late Onset Ventilator Associated Pneumonia (VAP) in a Tertiary Care Hospital of Bangladesh: A Prospective Cohort Study

Cited by 10 publications

References 20 publications

Microbial Profile of Pneumonia in Patients with Late Onset Ventilator Associated Pneumonia

Microbial Profile of Pneumonia in Patients with Late Onset Ventilator Associated Pneumonia

The clinical profile and outcomes of adult patients given intravenous colistin for multidrug-resistant gram negative infections in a Philippine tertiary hospital

Bacteriological profile of Tracheal aspirate and their Antimicrobial Sensitivity Pattern in a Tertiary Care Hospital in Dhaka city

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