Spectrum of Germ Cell Tumor (GCT): 5 Years’ Experience in a Tertiary Care Center and Utility of OCT4 as a Diagnostic Adjunct

Paramita, Paul; Agarwal, Preeti; Mili, Jain; Ridhi, Jaiswal; Sagar, Mala; Goel, MM

doi:10.1007/s13193-022-01522-w

Cited by 1 publication

(1 citation statement)

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“…According to a study by Ataikiru et al involving Romanian children with MGCT, 87.5% of cases before puberty and 64.7% after puberty had an EC component [57]. It primarily affects males and is extremely rare in females [95]. Germinoma can occur in both the gonads and the CNS.…”

Section: Malignant Saccrococygeal Germ Cell Tumormentioning

confidence: 99%

Role of Alpha-Fetoprotein (AFP) in Diagnosing Childhood Cancers and Genetic-Related Chronic Diseases

Głowska-Ciemny,

Szymanski,

Kuszerska

et al. 2023

Cancers

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Alpha-fetoprotein (AFP) is a protein commonly found during fetal development, but its role extends beyond birth. Throughout the first year of life, AFP levels can remain high, which can potentially mask various conditions from the neurological, metabolic, hematological, endocrine, and early childhood cancer groups. Although AFP reference values and clinical utility have been established in adults, evaluating AFP levels in children during the diagnostic process, treatment, and post-treatment surveillance is still associated with numerous diagnostic pitfalls. These challenges arise from the presence of physiologically elevated AFP levels, inconsistent data obtained from different laboratory tests, and the limited population of children with oncologic diseases that have been studied. To address these issues, it is essential to establish updated reference ranges for AFP in this specific age group. A population-based study involving a statistically representative group of patients could serve as a valuable solution for this purpose.

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Section: Malignant Saccrococygeal Germ Cell Tumormentioning

confidence: 99%