Spectrum of Haemoglobinopathies in a Tertiary Care Hospital of Armed Forces

Chopra, GS; Nair, Velu; Gupta, PK; Mishra, DK; Sharma, Aditi; Mathew, O P

doi:10.1016/s0377-1237(08)80005-6

Cited by 18 publications

(17 citation statements)

References 3 publications

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“…The frequency of thalassaemia is increased by consanguity & endogenous mating , it may be assumed that tribal community in India are facing the problem at large scale. 9 Chopra et al 10 This study provides a data on spectrum of haemoglobinopathy in rural based tertiary care hospital (Index Medical Collage & Hospital) for the first time.…”

Section: Resultsmentioning

confidence: 99%

Prevalence and spectrum of hemoglobinopathies in tertiary care centre in a rural area of Madhya Pradesh

et al. 2013

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Background: Haemoglobinopathies like thalassaemia and sickle cell anaemia etc are increasing due to unawareness of rural population. This study indicates type of haemoglobinopathies amongst the patients of a rural based tertiary care hospital in one year and nine months. Methods: Five hundred ten patients were studied during last one year and nine month for all suspected cases of haemolytic anaemia based on Complete Blood Count, Red cell indices and Peripheral blood smear examination. Sickling test, test for Hb F and haemoglobin electrophoresis with quantification of bands are done in all these cases Results: Out of all 510 cases of anaemia 461 cases (90.39%) were confirmed to nonhaemolytic anaemia whereas 49 cases (9.60%) had shown abnormal haemoglobin bands on electrophoresis. Out of these 49 cases 29 (59.18%) were Males and 20 (40.81%) were females. Most common Haemoglobinopathy observed was Sickle cell β Thalassaemia 23 (4.50%) followed by β Thalassaemia Trait 9 (1.76%), Sickle Cell trait 7 (1.37%). β Thalassaemia Major 5 (0.98%) & Sickle Cell Disease 5 (0.98%) have equal prevalence. The onset of disease was most prominent in Neonatal to pediatric age group including early adolescent (0-18 years) followed by reproductive age group (19- 45 years). Few cases of old age (46+ years) were detected. Conclusion: Study provides data on the spectrum & pattern of Haemoglobinopathies in a rural tertiary care centre. Screening of all anemic patients should be done for Haemoglobinopathy and proper Genetic counseling must be given to all cases to prevent incidence of cases in future generation. [Int J Res Med Sci 2013; 1(4.000): 482-486

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Section: Resultsmentioning

confidence: 99%

Prevalence and spectrum of hemoglobinopathies in tertiary care centre in a rural area of Madhya Pradesh

et al. 2013

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“…The mean MCH among carriers of hemoglobinopathies was significantly lower than normal cases in the study. A low MCH and a low MCV predicts the presence of thalassemia [9].…”

Section: Discussionmentioning

confidence: 99%

Use of NESTROFT as a screening test for the carriers of thalassemia major

Sharma

Gulati

2016

Int J Pediatr Res

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Objective: To evaluate the utility of NESTROFT as a screening test for carriers of thalassemia major. Design: prospective study. Settings and participants: Total 121 clinically normal siblings, of thalassemia major patients who are registered at thalassemia welfare society of J K LON hospital Kota, were selected randomly for study. Intervention: All cases were investigated for CBC, Mentzer's index, NESTROFT and HbA2 estimation by HPLC method. Result: Total 121 cases were screened for thalassemia carrier by HbA2 estimation using HPLC technique. Out of which total 59 (48.76%) cases showed HbA2 level ≥3.5%considered as carrier while rest 62 (51.24%) cases were having normal Hemoglobin pattern. The Sensitivity, specificity, positive predictive value and negative predictive value of MCV<80 are 89.83%, 46.77%, 61.62% and 82.85% respectively. The Sensitivity, specificity, positive predictive value and negative predictive value of Mentzer's index are 83.05%, 97.36%, 96.07% and 88.09 % respectively. The Sensitivity, specificity, positive predictive value and negative predictive value of NESTROF test are 93.22%, 88.70%, 88.7% and 93.22 % respectively. So NESTROFT is better test (sensitivity is 93.22% and negative predictive value is 93.22%) for screening for Thalassemia carrier. Conclusion: NESTROF test is reliable, cost effective and better screening test for Thalassemia carrier detection. Positive cases can be confirmed by HPLC. NESTROFT can be used in mass hemoglobinopathies screening programmes.

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“…18 Chopra et al revealed that out of 1032 participant, 258 (25%) cases had abnormal hemoglobin. 19 The issue of hemoglobinopathies in India is aggravated by the diversity of population. The gene frequency for various hemoglobinopathies varies across different regions of India.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hemoglobinopathies in different regions and castes of Uttar Pradesh, India -A hospital based study

et al. 2015

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Background: Thalasemia and other hemoglobinopathies are found in all the states of India and their prevalence is quite variable. In Uttar Pradesh very few studies are found which explore the spectrum of hemoglobinopathies. There is no such study which identifies the geographic distribution of high-risk communities with frequencies of hemoglobinopathies. Aim: Present study was carried out to determine the prevalence of hemoglobinopathies in different regions and castes of Uttar-Pradesh (UP) state. Materials and Methods: This is a preliminary community based cross-sectional, hospital based study, conducted at King George’s Medical University, Lucknow, Uttar- Pradesh. Subjects aged between 18 to 65 years were enrolled for sampling. The anticoagulated blood was used for performing CBC (complete blood count), and hemoglobin electrophoresis to measure hemoglobinopathies. Results: The present study revealed higher(28/194;19.5%,p<0.05) prevalence of hemoglobinopathies in Lucknow district as compared to other districts of Uttar-Pradesh and Brahmin caste having high frequency (33/112;29.5%) followed by Jaiswal (3/13;23.1%) and Arora (2/9;22.2%). Conclusion: The data regarding prevalence and distribution can be useful in prevention and management of various hemoglobinopathies which play a vital role in the hospital blood bank as well as in the formulation of transfusion policies.DOI: http://dx.doi.org/10.3126/ajms.v6i5.12339 Asian Journal of Medical Sciences Vol.6(5) 2015 21-25

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Spectrum of Haemoglobinopathies in a Tertiary Care Hospital of Armed Forces

Abstract: This study provides a comprehensive database on the spectrum of haemoglobinopathies in the Armed Forces. It is suggested that detection of HbA2 should be carried out in all the high-risk groups with anaemia.

Cited by 18 publications

References 3 publications

Prevalence and spectrum of hemoglobinopathies in tertiary care centre in a rural area of Madhya Pradesh

Prevalence and spectrum of hemoglobinopathies in tertiary care centre in a rural area of Madhya Pradesh

Use of NESTROFT as a screening test for the carriers of thalassemia major

Prevalence of hemoglobinopathies in different regions and castes of Uttar Pradesh, India -A hospital based study

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