Spectrum of hospitalized NeuroCOVID diagnoses from a tertiary care neurology centre in Eastern India

Bhansali, Sakhi; Bagrodia, Vaishali; Choudhury, Supriyo; Rahman, Simin; Golder, Mohua; Tiwari, Mona; Kumar, Hrishikesh

doi:10.1016/j.jocn.2021.09.008

Cited by 2 publications

(3 citation statements)

References 32 publications

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“…Although the frequencies of epilepsy (4.3%) and seizures (2.2%) were similar to studies from other regions in the world (5.7%-10.0%) [ 5 , 12 , 18 – 20 ], the proportion of patients with movement disorders (2.2%) in our study was lower than that of other studies from Europe (9.3%) [ 20 ].…”

Section: Discussionsupporting

confidence: 61%

Neurological disorders associated with COVID-19 in Sri Lanka

Chang,

Wijeyekoon,

Keshavaraj

et al. 2023

BMC Neurol

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Background Neurological manifestations of SARS-CoV-2 infection have been reported from many countries around the world, including the South Asian region. This surveillance study aimed to describe the spectrum of neurological disorders associated with COVID-19 in Sri Lanka. Methods COVID-19 patients manifesting neurological disorders one week prior and up to six weeks after infection were recruited from all the neurology centres of the government hospitals in Sri Lanka from May 2021 – May 2022. Data was collected using a structured data form that was electronically transmitted to a central repository. All patients were evaluated and managed by a neurologist. Data were analysed using simple descriptive analysis to characterise demographic and disease related variables, and simple comparisons and logistic regression were performed to analyse outcomes and their associations. Results One hundred and eighty-four patients with neurological manifestations associated with COVID-19 were recruited from all nine provinces in Sri Lanka. Ischaemic stroke (31%) was the commonest neurological manifestation followed by encephalopathy (13.6%), Guillain–Barre syndrome (GBS) (9.2%) and encephalitis (7.6%). Ischaemic stroke, encephalitis and encephalopathy presented within 6 days of onset of COVID-19 symptoms, whereas GBS and myelitis presented up to 10 days post onset while epilepsy and Bell palsy presented up to 20 – 40 days post onset. Haemorrhagic stroke presented either just prior to or at onset, or 10 – 25 days post onset of COVID-19 symptomatic infection. An increased frequency of children presenting with encephalitis and encephalopathy was observed during the Omicron variant predominant period. A poor outcome (no recovery or death) was associated with supplemental oxygen requirement during admission (Odds Ratio: 12.94; p = 0.046). Conclusions The spectrum and frequencies of COVID-19 associated neurological disorders in Sri Lanka were similar to that reported from other countries, with strokes and encephalopathy being the commonest. Requiring supplemental oxygen during hospitalisation was associated with a poor outcome.

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Section: Discussionsupporting

confidence: 61%

Neurological disorders associated with COVID-19 in Sri Lanka

Chang,

Wijeyekoon,

Keshavaraj

et al. 2023

BMC Neurol

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confidence: 99%

“…We read with great interest the article published recently by Bhansali et al [1] “Spectrum of hospitalized NeuroCOVID diagnoses from a tertiary care neurology centre in Eastern India”, where the authors investigated COVID-19 patients with neurological manifestations, showing that stroke and encephalopathy are the most frequently associated conditions in COVID-19 patients. Additionally, they found that neurological manifestations are independent of respiratory symptoms and fever [1] . We thank the authors for providing us with such valuable evidence, however, we would like to make a few comments on an invasive infectious condition of great importance, which can occur at different times of COVID-19 and which puts at risk the neurological integrity of the affected person: rhino-orbito-cerebral mucormycosis.…”

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confidence: 99%