Spectrum of imiquimod‐induced lupus‐like reactions: Report of two cases

Lupus‐like reaction following imiquimod treatment for actinic keratoses

“…Imiquimod is a topical inmunomodulator with antiviral and antineoplastic properties widely used in dermatology. [1][2][3][4][5][6][7] Beyond the approved indications (treatment of actinic keratosis, superficial F I G U R E 1 Clinical presentation and histological findings. (A) A well-demarcated, infiltrated, erythematous plaque on the left cheek.…”

“…Clinical picture included erythematous or scaly plaques located in photoexposed areas (facial region and trunk) developing weeks to months after imiquimod application. [1][2][3][4][5][6][7] The long interval from imiquimod treatment to lesions development is hard to explain and we have not found further information about this issue in the literature. Nevertheless, our case latency fits into the reported in previous cases.…”

“…Nevertheless, our case latency fits into the reported in previous cases. [1][2][3][4][5][6][7] Discontinuation of imiquimod and treatment with topical corticosteroids or hydroxychloroquine lead to resolution with no recurrence in most cases. [1][2][3][4][5][6][7] Autoantibody detection has shown variable results with four positive cases, two negative and three not reported.…”

“…[1][2][3][4][5][6][7] Discontinuation of imiquimod and treatment with topical corticosteroids or hydroxychloroquine lead to resolution with no recurrence in most cases. [1][2][3][4][5][6][7] Autoantibody detection has shown variable results with four positive cases, two negative and three not reported. [1][2][3][4][5][6][7] The usual histologic findings were interface dermatitis with apoptotic keratinocytes, occasional basement membrane vacuolization and prominent perivascular and periadnexal lymphocytic infiltrates.…”

“…[1][2][3][4][5][6][7] Autoantibody detection has shown variable results with four positive cases, two negative and three not reported. [1][2][3][4][5][6][7] The usual histologic findings were interface dermatitis with apoptotic keratinocytes, occasional basement membrane vacuolization and prominent perivascular and periadnexal lymphocytic infiltrates. [1][2][3][4][5][6][7] Dermal mucin deposition is rarely reported.…”