1991
DOI: 10.1016/0041-3879(91)90040-y
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Spectrum of immune reactivity to mycobacterial (BCG) antigens in healthy hospital contacts in South India

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1992
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Cited by 18 publications
(5 citation statements)
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“…In a recent study from Madras, south India, BCG vaccination of PPD-negative adults did not change the level of IFN-␥ or other cytokines studied (13). This supports our contention that the Mantoux status might be a host genetics-determined immune response (8,19,36).…”
Section: Discussionsupporting
confidence: 89%
“…In a recent study from Madras, south India, BCG vaccination of PPD-negative adults did not change the level of IFN-␥ or other cytokines studied (13). This supports our contention that the Mantoux status might be a host genetics-determined immune response (8,19,36).…”
Section: Discussionsupporting
confidence: 89%
“…Lymphoproliferative response to antigen stimulation has been widely used as in vitro correlates of cell-mediated immunity [34]. PBMCs from vaccinated and “sham-immunized” goats were used to assess the response to protoplasmic antigen of MAP.…”
Section: Discussionmentioning
confidence: 99%
“…and atypical mycobacteria in the endemic environment and the resultant memory. Such exposure has been suggested to be responsible for the spectrum of immune reactivity in endemic controls (3,12,22). The exposure and cross-reactivity might have resulted in expansion and persistence of a defined T-cell memory pool, performing immune surveillance.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, expression of the Th2 cytokines interleukin-10 (IL-10) and IL-4 is associated with Mycobacterium bovis BCG scar-negative non-DR2 status in patients (7). It has also been demonstrated that there is a spectrum of immune reactivity (delayed-type hypersensitivity versus serum antibodies) in hospital contacts and healthy individuals in southern India, and this finding has been confirmed in other countries where tuberculosis is highly endemic, such as Indonesia and Brazil (3,12,22). However, we are unaware of the epitope specificities of the responses.…”
mentioning
confidence: 93%