Spectrum of Malignant Lymphoma in a Tertiary Care Hospital of North Eastern India

Abstract

Background:The term malignant Lymphomas embrace a variable group of Proliferative diseases that originate in the Lymph node or extra nodal Lymphatic Tissue. It constitutes 3.69% of all Malignancies World Wide. The incidence of Lymphoma exhibits a marked Geographic variation in the World. Methods:The study included58 patients who were histologically diagnosed as Malignant lymphomas in our hospital, the paraffin embedded blocks of these cases were evaluated by a panel of immunohistochemistry markers by taking proper controls and using the standard protocol. Statistical analysis were performed by SPSS software.Results: Out of the 58 cases of Malignant Lymphoma 47 were diagnosed as Non Hodgkins Lymphoma and 11 cases (19%) as Hodgkins Lymphoma. Of these 58 cases of Malignant Lymphoma, adults were 51 and paediatric cases were 7, male female ratio was 2.6:1 and Non Hodgkins Lymphoma was Commoner. B cell Lymphomas were the predominant type accounts for 74.5% of all Non Hodgkins Lymphoma cases of these B cell Lymphomas Diffuse large B cell Lymphoma was the Predominant type.Among the T cell Lymphomas Anaplastic large cell Lymphoma was the commonest subtype. Nodular Sclerosis Cases were seen most commonly in the Hodgkins Category. Extra nodal Lymphomas were also seen in 35.6% cases with Tonsil being the commonest site. Conclusion:Non Hodgkins Lymphoma was significantly more common in this region and diffuse large B cell Lymphoma was the predominant type. A combination of Histopathology and a Meticulous Immunohistochemistry helps in properly solving the diagnostic challenges.