Spectrum of prostatic lesions

Aslam, Hafiz Muhammad; Shahid, Nazish; Shaikh, Naseem Ahmad; Shaikh, Hiba Arshad; Saleem, Saima; Mughal, Anum

doi:10.1186/1755-7682-6-36

Cited by 25 publications

(22 citation statements)

References 5 publications

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“…11 Basal cell hyperplasia was the other significant co-existing histopathological finding (4.15%). Basal cell hyperplasia was reported as coexistent finding in (5.4%) of cases Mittal et al and (3.85%) by monika et al 10,11 Two cases of granulomatous prostatitis negative for AFB were also seen and reported as nonspecific granulomatous prostatitis. Cribriform hyperplasia and squamous metaplasia were the other but less frequent histopathological findings.…”

Section: Discussionmentioning

confidence: 93%

The Spectrum of Histopathological Patterns Observed in Prostate Specimens in a Tertiary Care Hospital in Kashmir

Farooq¹,

Bilal²,

Khaliq³

et al. 2019

IJCMR

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Introduction: Prostate gland involved by a no. of benign and malignant diseases is a common cause of morbidity and mortality in the elderly men. The present study was an attempt to understand the histopathological spectrum of prostatic lesions in the specimens received by a tertiary care hospital.Material and Methods: 433 cases of prostatic specimens including TURP chips, TRUS guided biopsies and Prostatic specimens received in the Department of Pathology, Government Medical College Srinagar were included in the present study. There were 344 needle biopsies and 82 TURP chips. All the specimens were fixed in 10% neutral buffered formalin and thin sections were stained with Hematoxylin and Eosin stain (H&E stain). Relevant clinical data including age, the presenting complaints and S.PSA values in suspected cases of carcinoma prostate were recorded.Results: A total of 433 prostate specimens were received during the period of three years. The specimens included 344 TURP chips and 82 TRUS guided biopsies. 7 prostectomy specimens were also included. The age of the patients varied from 42 years to 89 years. There were 380 benign cases and 53 malignant cases. The most common presenting feature was increased frequency of micturition followed by difficulty in starting and stopping the stream of urine. Among benign lesions the most frequent histopathologi cal entity observed was benign nodular hyperplasia. The most common age of presentation was the sixth to seventh decade of life. Almost all neoplasms of the prostate were prostatic adenocarcinomas with most of the cases seen in the sixth to seventh decade of life with another peak in the seventh to eight decade of life. Conclusion:A variety of benign and malignant lesions are seen in prostatic specimens. These need to be differentiated and classified. Benign nodular hyperplasia is the most common benign lesion and prostatic adenocarcinoma is the most common malignant lesion of Prostate. Perineural invasion is a significant finding and guide. Serum PSA is a useful adjunct in cases where the values are higher.

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Section: Discussionmentioning

confidence: 93%

The Spectrum of Histopathological Patterns Observed in Prostate Specimens in a Tertiary Care Hospital in Kashmir

Farooq¹,

Bilal²,

Khaliq³

et al. 2019

IJCMR

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“…Our study not only provides a plausible clue as to how the cytostatic TGFβ pathway may be switched to pro‐tumorigenic mode by transcriptional and post‐translational dysregulation of certain TGFβ components, it also showed that the molecular pattern of TGFβ signaling is remarkably distinct in prostate cancer and BPH in spite of their commonalities with respect to risk factors, pathological drivers and symptoms. This is a novel and clinically useful finding since BPH is the most common non‐malignant lesion of prostate gland that often coexists with prostate cancer in aged men (Aslam et al, ).…”

Section: Discussionmentioning

confidence: 99%

Deregulated E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGFβ Signaling in Prostate Cancer

et al. 2016

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Transforming growth factor-β signaling exerts divergent effects on normal and cancer cells, although mechanism underlying this differential behavior remains unclear. In this study, expression of 94 genes pertaining to the TGF-β signaling pathway was compared between tumor and benign tissue samples from the human prostate gland to identify major discriminators driving prostate carcinogenesis. E2F5 was identified as one of the most deregulated genes in prostate cancer tissues, predominantly in samples with Gleason-score 6. Expression of other deregulated components of TGF-β signaling was examined by qRT-PCR, Western blot, and immune-staining. Function of E2F5 and p38 in prostate cancer was investigated using siRNA-treatment of PC3 cell-line followed by analyses of associated components and cell cycle. Observations revealed that E2F5 overexpression was accompanied by significantly higher phosphorylation of SMAD3 at Ser-208 in the linker region (pSMAD3L) and p38 in tumor tissue. A striking difference in SMAD3 phosphorylation, marked by preponderance of pSMAD3L and pSMAD3C (Ser-423 and 425) in tumor and benign tissues, respectively was noted. Co-localization of E2F5 with pSMAD3L in the nuclei of tumor and PC3 cells indicated a functional interface between the proteins. Downregulation of E2F5 and p38 in PC3 cells resulted in marked reduction of phosphorylation of SMAD3 and perturbation of cell cycle with an arrest of cells in G1 . Our findings unearthed that E2F5/p38 axis played a cardinal role in uncontrolled cellular proliferation in prostate cancer through pSMAD3L activation. It also underscores a strong potential for E2F5 to be incorporated as a tool in early detection of prostate cancer. J. Cell. Physiol. 231: 2482-2492, 2016. © 2016 Wiley Periodicals, Inc.

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“…The common age group involved in this series was 50-60 and 60-70 years as was ascertained in other studies. 3,13 Many literatures are present of studies in India and abroad diagnosing BNH as the highest percentage of cases. Outcome of some studies are similar to our findings of 73.91%.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of prostate gland lesions: a clinico-pathologic study in south-western Bihar, India

Kumar

Ahmad

2019

Int J Adv Med

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Background: Prostate gland is an endocrine dependent organ in males and age-related lesions involve it. Inflammation, benign nodular hyperplasia and tumours are the commonest to involve it worldwide. Occasionally some other pathological changes can also involve it. The study was carried out for the first time to know the spectrum and prevalence of prostate lesions which will be of help to the clinicians in this location.Methods: Retrospective study was carried out for a period of four years and out of surgical cases of males which underwent operative procedure, prostate cases were retrieved and in the department of pathology, haematoxylin and eosin stained slides were evaluated and diagnosed.Results: A total of 138 cases were included and five cases were excluded from this series. Benign nodular hyperplasia (73.9%) was the commonest finding followed by chronic prostatitis associated with hyperplasia (15.2%), atypical glandular hyperplasia (2.9%) and prostatic intraepithelial neoplasia (2.1%). Malignant tumours were 5.8% constituting adenocarcinoma prostate as the most common (62.5%). A case of hemangiopericytoma was also diagnosed.Conclusions: Benign nodular hyperplasia of prostate is the most common affliction among males starting at age 45 years. Early consultation and screening will be of immense value. Adenocarcinoma prostate may involve at age around 58 years.

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Spectrum of prostatic lesions

Cited by 25 publications

References 5 publications

The Spectrum of Histopathological Patterns Observed in Prostate Specimens in a Tertiary Care Hospital in Kashmir

The Spectrum of Histopathological Patterns Observed in Prostate Specimens in a Tertiary Care Hospital in Kashmir

Deregulated E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGFβ Signaling in Prostate Cancer

Spectrum of prostate gland lesions: a clinico-pathologic study in south-western Bihar, India

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