Spectrum of quality of life impairment in hypothyroidism

Jaeschke, Roman; Guyatt, Gordon; Cook, Deborah J.; Harper, S.; Gerstein, Hertzel C.

doi:10.1007/bf00451724

Cited by 67 publications

(53 citation statements)

References 13 publications

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“…It consists of 104 items, each representing a specific complaint, covering four domains: 'physical complaints', 'mood and emotions', 'energy and general well-being', and 'cognitive complaints' (27,47). The development of the CTQ was quite thorough.…”

Section: Hypothyroidism Questionnairesmentioning

confidence: 99%

“…The development of the CTQ was quite thorough. Based on a literature review, a list of symptoms or problems related to hypothyroidism, potentially responsive to treatment and likely to influence the quality of life of the patients was generated (27). This list was expanded through interviews with endocrinologists and patients.…”

Section: Hypothyroidism Questionnairesmentioning

confidence: 99%

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Quality of life in patients with benign thyroid disorders. A review

et al. 2006

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The importance of patient-reported outcomes such as health-related quality of life (HRQL) in clinical research is increasingly acknowledged. In order to yield valid results, the measurement properties of HRQL questionnaires must be thoroughly investigated. One aspect of such a validation process is the demonstration of content validity, i.e. that the questionnaire covers all relevant aspects. We review studies reporting on consequences of thyroid disorders and present the frequency of identified aspects, both overall HRQL issues and classical thyroid symptoms, in order to evaluate which issues are relevant for patients with thyroid diseases. Furthermore, existing questionnaires for thyroid patients are reviewed. A systematic search was performed in the Medline, Cinahl and Psycinfo databases and the reference lists of the relevant articles were hand-searched. Seventy-five relevant studies were identified. According to these studies, patients with untreated thyroid disease suffer from a wide range of symptoms and have major impairment in most areas of HRQL. Furthermore, the studies indicate that impairments in HRQL are also frequent in the long term. Six HRQL questionnaires for thyroid patients were identified. Generally, data supporting the validity of these questionnaires were sparse. According to the available literature, the quality of life of thyroid patients is substantially impaired over a wide range of aspects of HRQL in the untreated phase and continues to be so in many patients also in the long term. Studies systematically exploring the relative importance of these various aspects to thyroid patients are lacking, as is a comprehensive, validated thyroid-specific HRQL questionnaire.European Journal of Endocrinology 154 501-510

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Section: Hypothyroidism Questionnairesmentioning

confidence: 99%

Section: Hypothyroidism Questionnairesmentioning

confidence: 99%

Quality of life in patients with benign thyroid disorders. A review

et al. 2006

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“…Some questionnaires have been developed for specific thyroid diseases (4)(5)(6)(7)(8)(9)(10)(11)(12). However, a thoroughly validated questionnaire only exists for thyroid-associated ophthalmopathy (TAO) patients (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Validity and reliability of the novel thyroid-specific quality of life questionnaire, ThyPRO

Watt

Hegedűs²,

Grøenvold³

et al. 2010

European Journal of Endocrinology

174

177

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Background: Appropriate scale validity and internal consistency reliability have recently been documented for the new thyroid-specific quality of life (QoL) patient-reported outcome (PRO) measure for benign thyroid disorders, the ThyPRO. However, before clinical use, clinical validity and test-retest reliability should be evaluated. Aim: To investigate clinical ('known-groups') validity and test-retest reliability of the Danish version of the ThyPRO. Methods: For each of the 13 ThyPRO scales, we defined groups expected to have high versus low scores ('known-groups'). The clinical validity (known-groups validity) was evaluated by whether the ThyPRO scales could detect expected differences in a cross-sectional study of 907 thyroid patients. Test-retest reliability was evaluated by intra-class correlations of two responses to the ThyPRO 2 weeks apart in a subsample of 87 stable patients. Results: On all 13 ThyPRO scales, we found substantial and significant differences between the groups expected to have high versus low scores. Test-retest reliability was above 0.70 (range 0.77-0.89) for all scales, which is usually considered necessary for comparisons among patient groups, but below 0.90, which is the usual threshold for use in individual patients. Conclusion: We found support for the clinical validity of the new thyroid-specific QoL questionnaire, ThyPRO, and evidence of good test-retest reliability. The questionnaire is now ready for use in clinical studies of patients with thyroid diseases.

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“…In patients with SCH, symptoms may contribute to perceived impairment of healthrelated quality of life (13). Health status can be measured by the widely used generic Short Form-36 (SF-36) questionaire.…”

Section: Introductionmentioning

confidence: 99%

Health status in patients with sub-clinical hypothyroidism

Razvi

Ingoe²,

McMillan³

et al. 2005

eur j endocrinol

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Objective: Sub-clinical hypothyroidism (SCH) is a common disorder. People with this condition may have symptoms which could affect their perception of health. Therefore, the perceived health status of people with SCH was assessed and compared with population-matched norms. Design: A prospective cross-sectional survey. Methods: Seventy-one adults with SCH, age range 18-64 years were studied. Perceived health status was measured by the Short Form-36 (SF-36) version 2 questionaire, which has been validated in a UK population setting. The SF-36 has eight scales measuring physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotional and mental health. Their SF-36 scores were compared with UK normative data after matching for age and sex and are reported as z-scores. Results: Scores of all eight SF-36 scales were significantly lower in people with SCH compared with the normative population. A negative score (compared with zero of the normative population) indicates worse health status. The most significantly impaired aspects of health status were vitality and role limitations due to physical problems (role physical scale) with z-scores (95% confidence intervals) of 21.01 (2 0.74 to 2 1.29) and 20.73 (20.43 to 2 1.04) respectively. Thyroid autoimmunity did not influence the results. Conclusion: Perceived health status is significantly impaired in people with SCH when compared with UK normative population scores. This needs to be taken into consideration by clinicians when managing patients with this disease.European Journal of Endocrinology 152 713-717

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Spectrum of quality of life impairment in hypothyroidism

Cited by 67 publications

References 13 publications

Quality of life in patients with benign thyroid disorders. A review

Quality of life in patients with benign thyroid disorders. A review

Validity and reliability of the novel thyroid-specific quality of life questionnaire, ThyPRO

Health status in patients with sub-clinical hypothyroidism

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