Spectrum of skin disorders in human immunodeficiency virus‐infected patients in Singapore and the relationship to CD4 lymphocyte counts

Goh, Boon Kee; Chan, Roy; Sen, Priya; Theng, Colin; Tan, Hiok‐Hee; Wu, Yuan-Jing; Paton, Nicholas I.

doi:10.1111/j.1365-4632.2007.03164.x

Cited by 63 publications

(87 citation statements)

References 23 publications

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“…Seborrheic dermatitis was found to be the common non-infectious dermatoses by studies done by Munoz-Perez MA et al, Singh H et al and Sharma YK et al (18,20,21 ) , but studies by Goh BK et al and Chawhan SM et al (22,23) showed papular pruritic eruption as the common dermatoses. The prevalence of pigmentary disorders in our study was 5.1% and xerosis 4.5%.…”

Section: Discussionmentioning

confidence: 96%

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

Swamiappan¹,

Vijayabhaskar²,

Subbaiya³

et al. 2016

jemds

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Section: Discussionmentioning

confidence: 96%

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

Swamiappan¹,

Vijayabhaskar²,

Subbaiya³

et al. 2016

jemds

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“…In our patients, seborrheic dermatitis was observed in all stages of HIV infection. Very high incidences of psoriasis have been reported from Asia (up to 25%) in HIV-infected populations (18). In Western studies, on the other hand, 2%-4% incidences of psoriasis have been published (6).…”

Section: Discussionmentioning

confidence: 99%

Mucocutaneous manifestations and the relationship to CD4 lymphocyte counts among Turkish HIV/AIDS patients in İstanbul, Turkey

Aydın¹,

Karaosmanoğlu²,

Özeren³

et al. 2015

Turk J Med Sci

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Background/aim: Dermatologic findings differ among countries but no sufficient data about Turkish HIV-infected patients exist in the literature. Therefore, our aim in this study was to document the dermatologic manifestations and their relationships with CD4 cell counts among HIV/AIDS patients visiting our clinic for the first time in İstanbul, Turkey. Materials and methods:A retrospective analysis of 306 HIV/AIDS patients (260 men, mean age: 38.3 years) was done in a tertiary hospital in İstanbul from January 2006 to September 2012. Information on age, sex, transmission routes, socioeconomic and educational status, CD4 counts, and dermatologic findings was collected retrospectively from medical records. Results:Our analyses revealed at least 1 dermatologic disease in 111 of the 306 (36.2%) patients. Mean CD4 count of the patients was 393.64 cells/mm3 (range: 4-1270 cells/mm 3 ). Oral candidiasis (12.4%), herpes zoster (5.9%), dermatophytosis (5.4%), hyperpigmentation (5.2%), and folliculitis (4.6%) were the most common skin problems. Statistically significant correlation (P < 0.05) with low CD4 cell counts was found for oral candidiasis, folliculitis, herpes zoster, hyperpigmentation, xerosis, and Kaposi's sarcoma. Conclusion:Dermatologic manifestations in this study were identical to those described in most studies from Asia, and there were more manifestations as the HIV infection progressed and immune functions declined.

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“…Go BK et al [11] in Singapore report that out of 96 HIV-infected patients, 70% of patients developed lesions at the time of diagnosis, suggesting that HIV has a direct effect on the onset of psoriasis. This association is probably related to the overexpression of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) [11] [12].…”

Section: Discussionmentioning

confidence: 99%

Retrospective Study of 23 Cases of Psoriasis Association with HIV Infection Observed in the Department of Dermatology-STD in the University Hospital of Donka Conakry Guinea

Keita¹,

Soumah²,

Tounkara³

et al. 2018

JCDSA

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Introduction: The psoriasis is one of the inflammatory dermatoses with unknown etiology, with chronic evolution having episodic appearance and disappearance. Its prevalence in HIV patients varied from 2% to 5% in most of the times. Objective of this study was to describe the demographic, clinical and therapeutic characteristics of psoriasis patients infected with HIV. Methods: It is a descriptive retrospective study done from January 2003 to December 2013 based on the information from the hospital card of hospitalized patients and outpatients taken care in the department of Dermatology-STD for psoriasis at the University hospital center in Donka Conakry. We included all the cases of psoriasis associated with HIV infection diagnosed from clinical and paraclinical elements. Results: We recorded 23 (24.73%) cases of psoriasis associated with HIV infection among 93 patients observed for psoriasis in which there are 4 cases of psoriasis vulgaris, 10 cases of erythrodermic psoriasis and 9 cases of arthropathic form among these numbers. We had 7 women and 16 men. The medium age of our patients was 44.5 ± 12 years [27 -62 years]. The delayed duration time of consultation varied from 30 to more than 180 days. The psoriasis was the circumstance of the discovery of the HIV infection among 55% of cases. The pruritus was the functional sign which is the most frequent in 20 cases among 23 cases and 71.4% of cases were accompanied with pain. Family history was found in 7.10% of cases. Anxiety was the dominant factor cause in 42% and the infection 38%. The cutaneous alteration was noted in all patients; 92.9% of patients had nails alteration and intertrigineous association in 78.6% of cases. The clinical forms found were psoriasis The complicated forms like erythrodermic and arthropathic psoriasis were frequent in patients whose total CD4 < 350 cells/µl about 65%. The most frequently encountered co-morbidity was tuberculosis (9 cases). The use of traditional therapeutic means was noted in 50% of cases. The local treatment was based on dermocorticoid and keratolylic drugs. The general treatment received by all patients was antiretroviral medication and Methotrexate. Discussion: Our results are of course not representing all the cases of psoriasis in Guinea but it gives us an idea of the importance of HIV and psoriasis association and the influence of immunodepression inducted by HIV during the evolution of psoriasis. The demographic, clinical and therapeutic characteristics described in our patients were near those reported by more authors. Conclusion: HIV-associated psoriasis does not appear to be familial. Serious clinical forms occur in highly immunocompromised patients.

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Spectrum of skin disorders in human immunodeficiency virus‐infected patients in Singapore and the relationship to CD4 lymphocyte counts

Abstract: A preponderance of inflammatory dermatoses and an absence of skin tumors characterized this study. A low CD4 cell count was associated with a higher number of skin disorders and an increased incidence of PPE, psoriasis, and adverse drug eruptions.

Cited by 63 publications

References 23 publications

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

Pattern of Mucocutaneous Manifestations of Hiv Infected Patients: A Retrospective Study

Mucocutaneous manifestations and the relationship to CD4 lymphocyte counts among Turkish HIV/AIDS patients in İstanbul, Turkey

Retrospective Study of 23 Cases of Psoriasis Association with HIV Infection Observed in the Department of Dermatology-STD in the University Hospital of Donka Conakry Guinea

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