2024
DOI: 10.1101/2024.03.11.24303880
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Spectrum of somatic mutational features of colorectal tumors in ancestrally diverse populations

Marco Matejcic,
Jamie K. Teer,
Hannah J. Hoehn
et al.

Abstract: Ancestrally diverse and admixed populations, including the Hispanic/Latino/a/x/e community, are underrepresented in cancer genetic and genomic studies. Leveraging the Latino Colorectal Cancer Consortium, we analyzed whole exome sequencing data on tumor/normal pairs from 718 individuals with colorectal cancer (128 Latino, 469 non-Latino) to map somatic mutational features by ethnicity and genetic ancestry. Global proportions of African, East Asian, European, and Native American ancestries were estimated using A… Show more

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